INTERFERON-GAMMA - THE MAJOR MEDIATOR OF RESISTANCE AGAINST TOXOPLASMA-GONDII
INTERFERON-GAMMA - THE MAJOR MEDIATOR OF RESISTANCE AGAINST TOXOPLASMA-GONDII
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DOI：
10.1126/science.3128869
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发表时间：
1988-04-22
期刊：
影响因子：
56.9
通讯作者：
REMINGTON, JS
中科院分区：
文献类型：
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作者：
SUZUKI, Y;ORELLANA, MA;REMINGTON, JS
给小鼠注射干扰素-γ的单克隆抗体。研究这种淋巴因子的内源性产生在抵抗弓形虫孢子虫感染中的重要性。腹腔感染T.未接受抗体的弓形虫存活并发展为慢性T.弓形虫感染，而接受单克隆抗体的感染小鼠死于弓形虫病。巨噬细胞的激活，杀死T。单克隆抗体可抑制弓形虫体内抗体的产生，而抗弓形虫抗体的产生则不明显。弓形虫没有被抑制。干扰素-γ的抗体可以消除小鼠对急性弓形虫感染的抵抗力，表明这种淋巴因子是宿主抵抗这种寄生虫的重要介质。
Mice were injected with a monoclonal antibody to interferon-.gamma. to examine the importance of endogenous production of this lymphokine in resistance against infection with the sporozoan parasite Toxoplasma gondii. Mice with intraperitoneal infections of T. gondii that received no antibody survived and developed chronic T. gondii infection, whereas the infected mice that received the monoclonal antibody died of toxoplasmosis. The activation of macrophages, which kill T. gondii in vivo, was inhibited by administration of the monoclonal antibody, but the production of antibodies to T. gondii was not suppressed. The fact that an antibody to interferon-.gamma. can eliminate resistance to acute Toxoplasma infection in mice suggests that this lymphokine is an important mediator of host resistance to this parasite.