Hypertension Impairs Leptomeningeal Collateral Growth After Common Carotid Artery Occlusion: Restoration by Antihypertensive Treatment
Hypertension Impairs Leptomeningeal Collateral Growth After Common Carotid Artery Occlusion: Restoration by Antihypertensive Treatment
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DOI：
10.1002/jnr.22522
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发表时间：
2011-01-01
影响因子：
4.2
通讯作者：
Kitagawa, Kazuo
中科院分区：
文献类型：
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作者：
Omura-Matsuoka, Emi;Yagita, Yoshiki;Kitagawa, Kazuo
慢性轻度灌注不足已被证明扩大软脑膜侧支血管在正常小鼠脑。本研究的目的是阐明高血压对慢性低灌注后软脑膜侧支血管发育的影响。在血压正常的大鼠，单侧颈总动脉（CCA）闭塞扩大软脑膜侧支血管。CCA闭塞还保留了大脑中动脉（MCA）闭塞14天后的残余脑血流量（CBF）并缩小了梗死范围。相比之下，在SHR，CCA闭塞既没有扩大软脑膜吻合，也没有显示保护作用后，MCA闭塞。然而，使用血管紧张素II AT 1受体阻滞剂降低血压恢复了CCA闭塞对侧支生长以及MCA闭塞后残余CBF和梗死面积的有益作用。正常血压大鼠CCA闭塞后14天观察到的CBF自动调节曲线的适应性反应在未治疗的SHR中受损，但在降压治疗后恢复。总之，SHR在颈总动脉闭塞后，软脑膜侧支循环的生长受到损害，但降压治疗恢复了颈总动脉闭塞对侧支循环的有益作用。(C)2010 Wiley-Liss，Inc.
Chronic mild hypoperfusion has been shown to enlarge pial collateral vessels in normal mouse brains. The purpose of this study was to clarify the effect of hypertension on pial collateral vessel development after chronic hypoperfusion using spontaneously hypertensive rats (SHR). In normotensive rats, unilateral common carotid artery (CCA) occlusion enlarged leptomeningeal collateral vessels. CCA occlusion also preserved residual cerebral blood flow (CBF) and attenuated infarct size after middle cerebral artery (MCA) occlusion 14 days later. In contrast, in SHR, CCA occlusion neither enlarged the leptomeningeal anastomosis nor showed protective effects after MCA occlusion. However, decreasing blood pressure using an angiotensin II AT1 receptor blocker restored the beneficial effect of CCA occlusion on collateral growth as well as on residual CBF and infarct size after MCA occlusion. Adaptive responses in CBF autoregulation curves observed 14 days after CCA occlusion in normotensive rats were impaired in untreated SHR, but were restored after antihypertensive treatment. In conclusion, SHR have impaired leptomeningeal collateral growth after CCA occlusion, but antihypertensive treatment restores the beneficial effect of CCA occlusion on collateral circulation. (C) 2010 Wiley-Liss, Inc.