Plasma zinc in hypertension/toxemia and other reproductive variables in adolescent pregnancy.
Plasma zinc in hypertension/toxemia and other reproductive variables in adolescent pregnancy.
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青少年妊娠高血压/毒血症和其他生殖变量中的血浆锌。
DOI：
10.1093/ajcn/34.11.2367
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
H. Batson
中科院分区：
文献类型：
--
作者：
F. Cherry;E. A. Bennett;G. Bazzano;L. Johnson;G. Fosmire;H. Batson
在新奥尔良慈善医院进行了一项研究，其中包括272名青少年孕妇，以确定妊娠结局与入组时测量的血浆锌水平之间的关系。对锌状态与样本采集时妊娠阶段校正的妊娠成功率相关参数进行回归分析。根据有无并发症对各组进行方差分析，并使用协方差分析来分析二分组。发现血浆锌水平较低，但差异很大（平均值= 58 +/- 12.6微克/分升）。锌值在收集时随妊娠阶段而显著不同，回归系数表明下降0.07微克/分升/天。血浆锌水平与血红蛋白、红细胞、铁蛋白、叶酸呈显著相关。至于妊娠过程中，妇女经历高血压/毒血症被发现有显着降低血浆锌水平。在出生时显示先天性缺陷的婴儿中，那些有隐睾和跖骨内翻的婴儿是由血浆锌远低于该组平均值的母亲分娩的。这些结果表明，需要调查的饮食模式和锌摄入量对母体血浆锌水平和妊娠结局的影响，进一步阐明锌在人类生殖，特别是妊娠高血压的作用。
A study was conducted at Charity Hospital, New Orleans, among 272 adolescent pregnant women to ascertain the relationship of pregnancy outcome to plasma zinc level measured once at the time of enrollment. Regression analyses were performed on zinc status versus parameters concerning success of pregnancy corrected for gestational stage at specimen collection. Analysis of variance was performed on groups according to presence or absence of complications, with analyses of covariance used to analyze dichotomous groups. Low, though widely variable, plasma zinc levels were found (mean = 58 +/- 12.6 micrograms/dl). Zinc values differed significantly by gestational stage at collection, the regression coefficient indicating a decline of 0.07 micrograms/dl/day. Plasma zinc level correlated significantly with Hb, red blood cells, ferritin, and folic acid. As to course of pregnancy, women experiencing hypertension/toxemia were found to have significantly lower plasma zinc level. Among infants displaying congenital defects at birth those with undescended testes and metatarsus varus were delivered by mothers whose plasma zinc was well below the mean for the group. These findings indicate the need to investigate the influence of dietary patterns and zinc intake on maternal plasma zinc level and pregnancy outcome, further delineating the role of zinc in human reproduction, particularly hypertension of pregnancy.