An evaluation of thresholding techniques in fMRI analysis
An evaluation of thresholding techniques in fMRI analysis
复制标题
DOI：
10.1016/j.neuroimage.2003.12.047
复制
发表时间：
2004-05-01
期刊：
影响因子：
5.7
通讯作者：
Rowe, DB
中科院分区：
文献类型：
--
作者：
Logan, BR;Rowe, DB
本文回顾并比较了在单受试者fMRI数据集中识别活动体素的个体体素阈值方法。描述了可用于校准激活阈值的不同错误率。我们讨论了将每个错误率控制在预定水平a的方法，包括忽略测试统计量之间空间相关性的简单程序以及包含这种相关性信息的更详细的程序。通过仿真研究显示了方法的工作特性，表明所使用的错误率对阈值法的灵敏度有重要影响，而考虑相关性对阈值法的灵敏度影响不大。因此，所描述的简单程序很好地适用于大多数单受试者fMRI实验的阈值设定，并被推荐使用。通过一个真实的双侧手指轻敲实验，对该方法进行了说明。(C) 2004爱思唯尔公司版权所有。
This paper reviews and compares individual voxel-wise thresholding methods for identifying active voxels in single-subject fMRI datasets. Different error rates are described which may be used to calibrate activation thresholds. We discuss methods which control each of the error rates at a prespecified level a, including simple procedures which ignore spatial correlation among the test statistics as well as more elaborate ones which incorporate this correlation information. The operating characteristics of the methods are shown through a simulation study, indicating that the error rate used has an important impact on the sensitivity of the thresholding method, but that accounting for correlation has little impact. Therefore, the simple procedures described work well for thresholding most single-subject fMRI experiments and are recommended. The methods are illustrated with a real bilateral finger tapping experiment. (C) 2004 Elsevier Inc. All rights reserved.