Hand, foot and mouth disease complicated with central nervous system involvement in Taiwan in 1980-1981
Hand, foot and mouth disease complicated with central nervous system involvement in Taiwan in 1980-1981
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DOI：
10.1016/s0929-6646(09)60236-9
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发表时间：
2007-02-01
影响因子：
3.2
通讯作者：
Huang, Li-Min
中科院分区：
文献类型：
--
作者：
Chang, Luan-Yin;Lee, Chin-Yun;Huang, Li-Min
1980-1981年台湾爆发的手足口病（HFMD）中发现了16例与中枢神经系统受累有关的病例：9例患有脊髓灰质炎样综合征，4例患有脑炎或脑脊髓炎，1例患有小脑炎，2例患有无菌性脑膜炎。他们均出现发烧症状，其中 5 人 (31%) 出现肌阵挛，15 人 (93%) 患有手足口病。他们的平均血液白细胞计数为12,490/μL，其中5人（310/0）白细胞增多（>15,000/μL）；平均脑脊液 (CSF) 白细胞计数为 156/μL，CSF 蛋白为 57 mg/dL，CSF 葡萄糖为 57 mg/dL。 2例手足口病合并脑炎患者住院1天内死亡，其中1例出现类似心肌炎的急性心肺衰竭。二十年后，至少一名男性患者出现了类似脊髓灰质炎综合症的后遗症，因此免服兵役。临床严重程度与 1998 年 EV71 流行病相当。
Sixteen cases from the 1980-1981 Taiwan outbreak of hand, foot and mouth disease (HFMD) associated with central nervous system involvement were identified: nine had polio-like syndrome, four had encephalitis or encephalomyelitis, one had cerebellitis, and two had aseptic meningitis. They all had fever, five (31%) had documented myoclonic jerk, and 15 (93%) had HFMD. Their mean blood leukocyte count was 12,490/mu L, and five (310/0) had leukocytosis (> 15,000/mu L); mean cerebrospinal fluid (CSF) leukocyte count was 156/mu L, CSF protein was 57 mg/dL and CSF glucose was 57 mg/dL. Two patients with HFMD plus encephalitis died within 1 day of hospitalization, and one of them had acute cardiopulmonary failure mimicking myocarditis. Twenty years later, at least one male patient had sequelae of polio-like syndrome and was therefore exempted from military service. Clinical severity was comparable to the 1998 EV71 epidemic.