The relationship between cholesterol level and Alzheimer's disease-associated APP proteolysis/Abeta metabolism.
The relationship between cholesterol level and Alzheimer's disease-associated APP proteolysis/Abeta metabolism.
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胆固醇水平与阿尔茨海默病相关的 APP 蛋白水解/Abeta 代谢之间的关系。
DOI：
10.1080/1028415x.2017.1416942
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发表时间：
2018
影响因子：
3.6
通讯作者：
Huanhuan Wang
中科院分区：
文献类型：
--
作者：
Chaoqun Wang;Yikai Shou;Jie Pan;Yue Du;Cuiqing Liu;Huanhuan Wang
在全球范围内，阿尔茨海默病（AD）是老年人群中最常见的神经退行性疾病，其标志是淀粉样β（Aβ）肽。能量代谢和AD发病机制被认为是相互影响的。不同的胆固醇水平被认为影响神经毒性Aβ生成的各个步骤，包括淀粉样前体蛋白（APP）蛋白水解和α-、β-和γ-分泌酶的相应活性。此外，已证明胆固醇介导Aβ代谢，如其纤维化、运输、降解和清除过程。本综述详细讨论了胆固醇水平与APP蛋白水解和Aβ代谢的各个方面之间的密切相互作用。
Globally, Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the elderly population, the hallmark of which is amyloid β (Aβ) peptide. Energy metabolism and AD pathogenesis are believed to influence one another. Different cholesterol levels are thought to influence various steps in neurotoxic Aβ generation, including amyloid precursor protein (APP) proteolysis and the corresponding activities of α-, β-, and γ-secretases. In addition, cholesterol has been proved to mediate Aβ metabolism, such as its fibrillation, transportation, degradation, and clearance processes. The current review discusses in detail the intimate interaction between the cholesterol level and the various aspects of APP proteolysis and Aβ metabolism.