Transcranial alternating current stimulation over the prefrontal cortex enhances episodic memory recognition
Transcranial alternating current stimulation over the prefrontal cortex enhances episodic memory recognition
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DOI：
10.1007/s00221-019-05543-w
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发表时间：
2019-04
影响因子：
2
通讯作者：
Tomonori Nomura;Akihiko Asao;Ayumi Kumasaka
中科院分区：
文献类型：
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作者：
Tomonori Nomura;Akihiko Asao;Ayumi Kumasaka
目前尚不清楚经颅交流电刺激（tACS）是否会影响情景记忆，而传递到左前额叶皮层（PFC）的伽马振荡对长期记忆保留的影响尚未得到充分研究。我们检查了左PFC上的tACS是否增强了情景记忆的识别。这项研究招募了36名健康的年轻成年志愿者。参与者被随机分配到tACS组[n= 18；14个女性;平均年龄±标准差（SD）： 21.2±0.4岁]或假对照组[n= 18；14个女性;平均年龄±SD: 21.2±0.4岁]。在第1天的学习任务和第2天的识别任务中，参与者接受了tACS或假刺激。识别任务也在第1天和第7天进行，并在所有三个时间点（第1、2和7天）测量反应准确性。与假对照组相比，tACS组的患者能够更好地保持长期记忆。这些发现表明，左侧PFC上的tACS增强了健康年轻人对情景记忆的识别。
It remains unknown whether transcranial alternating current stimulation (tACS) affects episodic memory and the effect of gamma oscillations delivered to the left prefrontal cortex (PFC) on long-term memory retention has not been fully investigated. We examined whether tACS over the left PFC enhances recognition of episodic memory. The study enrolled 36 healthy young adult volunteers. The participants were randomly assigned to either a tACS group [n= 18; 14 females; mean age ± standard deviation (SD): 21.2 ± 0.4 years] or a sham-control group [n= 18; 14 females; mean age ± SD: 21.2 ± 0.4 years]. Participants received either tACS or sham stimulation both during the learning task that was conducted on day 1 and during a recognition task on day 2. The recognition task was also conducted on days 1 and 7, and response accuracy was measured at all three time points (days 1, 2, and 7). Patients in the tACS group were better able to retain long-term memory than those in the sham-control group. These findings suggest that tACS over the left PFC enhances recognition of episodic memory in healthy young adults.