Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations.
Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations.
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DOI：
10.1016/j.cmet.2017.02.016
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发表时间：
2017-03-07
期刊：
影响因子：
29
通讯作者：
Patti ME
中科院分区：
文献类型：
--
作者：
Sales VM;Ferguson-Smith AC;Patti ME
人类和动物研究都表明，生命早期所经历的环境暴露对成年疾病的风险有很大影响。此外，父母在宫内或产后生活中所经历的环境暴露也会影响其后代的健康，从而在几代人之间引发疾病风险循环。从这个角度来看，我们关注生殖细胞的表观遗传机制，包括DNA甲基化、组蛋白修饰和非编码rna，它们共同提供了先前环境暴露的非遗传分子遗产，并影响转录调节、发育轨迹和后代成年疾病风险。Sales等人提供了环境暴露，特别是宫内环境暴露如何影响成年期代谢性疾病风险的观点。此外，早期暴露和成年父母的代谢性疾病都可以调节生殖细胞的表观遗传调节，从而提供非遗传分子遗产来影响后代的健康。
Both human and animal studies indicate that environmental exposures experienced during early life can robustly influence risk for adult disease. Moreover, environmental exposures experienced by parents during either intrauterine or postnatal life can also influence the health of their offspring, thus initiating a cycle of disease risk across generations. In this perspective, we focus on epigenetic mechanisms in germ cells, including DNA methylation, histone modification, and non-coding RNAs, which collectively may provide a non-genetic molecular legacy of prior environmental exposures and influence transcriptional regulation, developmental trajectories, and adult disease risk in offspring. Sales et al. provide perspective on how environmental exposures, particularly those experienced during intrauterine life, can influence metabolic disease risk in adulthood. Moreover, both early-life exposures and metabolic disease in adult parents can modulate epigenetic regulation in germ cells, thus providing a non-genetic molecular legacy to influence health of subsequent generations.