Age-dependent antidepressant pharmacogenomics:: polymorphisms of the serotonin transporter and G protein β3 subunit as predictors of response to fluoxetine and nortriptyline
Age-dependent antidepressant pharmacogenomics:: polymorphisms of the serotonin transporter and G protein β3 subunit as predictors of response to fluoxetine and nortriptyline
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DOI：
10.1017/s1461145703003663
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发表时间：
2003-12-01
影响因子：
4.8
通讯作者：
Kennedy, MA
中科院分区：
文献类型：
--
作者：
Joyce, PR;Mulder, RT;Kennedy, MA
在169名随机接受氟西汀或去甲替林治疗的抑郁症患者中，我们检查了5-羟色胺转运蛋白和G蛋白β 3亚基的多态性是否影响对这些抗抑郁药的反应。对于25岁以下的抑郁症患者，G蛋白β 3亚单位的T等位基因与去甲替林反应明显较差相关，而5-羟色胺转运体多态性不能预测抗抑郁反应。然而，在25岁或25岁以上的患者中，G蛋白β 3多态性不能预测抗抑郁反应，而5-羟色胺转运体的ss基因型与氟西汀和去甲替林的不良反应相关。这些不同年龄的抗抑郁药反应的药物遗传学预测因子可能为理解儿童/青少年和成人抑郁症药物反应的不连续性提供线索。
In 169 depressed patients randomized to treatment with either fluoxetine or nortriptyline, we examined whether polymorphisms of the serotonin transporter and the G protein beta3 subunit influenced response to these anti depressants. For depressed patients under the age of 25 yr the T allele of the G protein beta3 subunit was associated with a markedly poorer response to nortriptyline, while serotonin transporter polymorphisms did not predict antidepressant response. However, in patients 25 yr or older, the G protein beta3 polymorphisms did not predict antidepressant response, while the ss genotype of the serotonin transporter was associated with a poorer response to both fluoxetine and nortriptyline. These differential pharmacogenetic predictors of antidepressant response by age, may provide clues to understanding the discontinuities in pharmacological responsiveness of child/adolescent and adult depressive disorders.