Recovery of hippocampal network connectivity correlates with cognitive improvement in mild Alzheimer's disease patients treated with donepezil assessed by resting-state fMRI.
Recovery of hippocampal network connectivity correlates with cognitive improvement in mild Alzheimer's disease patients treated with donepezil assessed by resting-state fMRI.
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DOI：
10.1002/jmri.22662
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发表时间：
2011-10
影响因子：
4.4
通讯作者：
Li, Shi-Jiang
中科院分区：
文献类型：
--
作者：
Goveas, Joseph S.;Xie, Chunming;Ward, B. Douglas;Wu, Zhilin;Li, Wenjun;Franczak, Malgorzata;Jones, Jennifer L.;Antuono, Piero G.;Li, Shi-Jiang
旨在确定轻度 AD 受试者接受 12 周多奈哌齐治疗后认知改善的神经相关性。使用静息态功能连接 MRI (R-fMRI) 测量 14 名轻度 AD 和 18 名年龄匹配的正常 (CN) 受试者的海马功能连接 (HFC)。 AD 受试者在基线时和多奈哌齐治疗后进行扫描。 CN 受试者仅在基线时进行扫描，作为识别与海马体相关或反相关区域的参考。每次扫描之前，参与者都会接受认知、行为和功能评估。多奈哌齐治疗后，通过简易精神状态检查评分测量的认知改善的神经相关性在左侧海马旁回、背外侧前额叶皮层（DLPFC）和额下回中被发现。 AD 评估量表认知分量表得分的改善与左侧 DLPFC 和中额回的 HFC 变化相关。网络连接的更强恢复与认知能力的改善相关。 R-fMRI 可以为临床药理学试验中大脑对 AD 治疗的功能反应提供新的见解，也可以预测临床反应。
To identify the neural correlates of cognitive improvement in mild AD subjects, following 12 weeks of donepezil treatment. Resting-state functional connectivity MRI (R-fMRI) was used to measure the hippocampal functional connectivity (HFC) in 14 mild AD and 18 age-matched normal (CN) subjects. AD subjects were scanned at baseline and after donepezil treatment. CN subjects were scanned only at baseline as a reference to identify regions correlated or anticorrelated to the hippocampus. Before each scan, participants underwent cognitive, behavioral and functional assessments. After donepezil treatment, neural correlates of cognitive improvement measured by Mini-Mental State Examination scores were identified in the left parahippocampus, dorsolateral prefrontal cortex (DLPFC) and inferior frontal gyrus. Improvement in AD Assessment Scale-cognitive subscale scores correlated with the HFC changes in the left DLPFC and middle frontal gyrus. Stronger recovery in the network connectivity was associated with cognitive improvement. R-fMRI may provide novel insight into the brain's functional responses to AD treatment in clinical pharmacological trials, and also may predict clinical response.
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影响因子：
105.7
作者：
Kaduszkiewicz, H;Zimmermann, T;van den Bussche, H
通讯作者：
van den Bussche, H
影响因子：
4.8
作者：
Birn, Rasmus M.;Murphy, Kevin;Bandettini, Peter A.
通讯作者：
Bandettini, Peter A.
影响因子：
11
作者：
Rombouts, SARB;Barkhof, F;Scheltens, P
通讯作者：
Scheltens, P
影响因子：
9.9
作者：
Rogers, SL;Farlow, MR;Walshe, TM
通讯作者：
Walshe, TM
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V