Differences in patient postoperative and long-term outcomes between obstructive and perforated colonic cancer
Differences in patient postoperative and long-term outcomes between obstructive and perforated colonic cancer
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DOI：
10.1016/j.amjsurg.2007.02.027
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发表时间：
2008-04-01
影响因子：
3
通讯作者：
Salazar, Ramon
中科院分区：
文献类型：
--
作者：
Biondo, Sebastiano;Kreisler, Esther;Salazar, Ramon
背景：这项观察性研究的目的是分析接受紧急根治性手术的梗阻性和穿孔性结肠癌患者之间的差异。方法：1994年1月至2000年12月期间，被认为因复杂性结肠癌接受根治性切除的患者被考虑纳入研究。他们被分为两组：阻塞性癌症（OC）患者和穿孔性癌症（PC）患者。主要终点是术后结果和长期总生存率、癌症相关生存率和肿瘤复发。 结果：在 236 名患者中，155 名患者 (65.7%) 被认为手术是根治性的，旨在治愈：OC 组 117 名患者，PC 组 38 名患者。两组之间的根治性手术百分比没有观察到统计学差异（P = .63）。总体术后死亡率为 12.2%：OC 组有 14 名患者，PC 组有 5 名患者 (P = .839)。整个系列的总生存率、无复发概率和癌症相关生存率分别为 64.57%、67.72% 和 73.03%。两组在肿瘤复发、复发类型、总生存率、无复发概率和 5 年癌症相关生存率方面没有差异。结论：根据我们的经验，穿孔结肠癌患者的长期结果似乎并不比 OC 患者更差。需要进行更大系列的研究以进行进一步的调查。 (c) 2008 Elsevier Inc. 保留所有权利。
Background: The aim of this observational study was to analyze the differences between patients with obstructive and perforated colonic cancer who managed with emergency curative surgery.Methods: Between January 1994 and December 2000, patients deemed to have undergone curative resection for complicated colonic cancer were considered for inclusion in the study. They were classified into 2 groups: patients with obstructive cancer (OC) and patients with perforated cancer (PC). The main end points were postsurgical outcomes and long-term overall survival, cancer-related survival, and tumor recurrence.Results: Of the 236 patients, surgery was deemed to be radical and per, formed with intent to cure in 155 patients (65.7%): 117 patients in the OC group and 38 patients in the PC-group. No statistical differences were observed between the percentage of radical surgery between the 2 groups (P = .63). The overall postsurgical mortality rate was 12.2%: 14 patients in the OC group and 5 patients in the PC group (P = .839). Overall survival, probability of being free of recurrence, and cancer-related survival of the entire series were 64.57%, 67.72% and 73.03%, respectively. There were no differences between the 2 groups with respect to tumor recurrence, type of recurrence, overall survival, probability of being free of recurrence, and cancer-related survival at 5 years.Conclusions: In our experience, patients with perforated colonic cancer do not seem to show worse long-term outcomes than those with OC. Studies with larger series are needed for further investigations. (c) 2008 Elsevier Inc. All rights reserved.