Neural development of selective attention and response inhibition
Neural development of selective attention and response inhibition
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DOI：
10.1016/s1053-8119(03)00404-x
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发表时间：
2003-10-01
期刊：
影响因子：
5.7
通讯作者：
Mesulam, MM
中科院分区：
文献类型：
--
作者：
Booth, JR;Burman, DD;Mesulam, MM
在功能性磁共振成像（fMRI）过程中，研究了12名儿童（9至12岁）和12名成人（20至30岁）在两项认知任务上的大脑激活差异。空间选择性注意的测量与视觉搜索的一个连接目标（红色三角形）在一个领域的干扰和反应抑制与去不去任务进行了测量。在选择性注意任务中，儿童的前扣带回和丘脑比成人表现出更大的激活。有很大的发展差异，在反应抑制任务，儿童表现出更大的激活比成人在额-纹状体网络，包括扣带回中部，内侧额回，内侧方面的双边上级额回，和左侧的尾状核。儿童也表现出更大的双边激活的反应抑制任务，在后扣带回，丘脑和丘脑-杏仁核区域。反应抑制任务上的广泛发育差异与额-纹状体网络的长期成熟一致。(C)2003年爱思唯尔公司All rights reserved.
Brain activation differences between 12 children (9- to 12-year-olds) and 12 adults (20- to 30-year-olds) were examined on two cognitive tasks during functional magnetic resonance imaging (fMRI). Spatial selective attention was measured with the visual search for a conjunction target (red triangle) in a field of distracters and response inhibition was measured with a go no-go task. There were small developmental differences in the selective attention task, with children showing greater activation than adults in the anterior cingulate and thalamus. There were large developmental differences in the response inhibition task, with children showing greater activation than adults in a fronto-striatal network including middle cingulate, medial frontal gyrus, medial aspects of bilateral superior frontal gyrus, and the caudate nucleus on the left. Children also showed greater bilateral activation for the response inhibition task in posterior cingulate, thalamus and the hippocampo-amygdaloid region. The extensive developmental differences on the response inhibition task are consistent with the prolonged maturation of the fronto-striatal network. (C) 2003 Elsevier Inc. All rights reserved.