A LONGITUDINAL-STUDY OF SOMATOSENSORY, BRAIN-STEM AUDITORY AND PERIPHERAL SENSORY-MOTOR CONDUCTION DURING VITAMIN-E-DEFICIENCY IN THE RAT
A LONGITUDINAL-STUDY OF SOMATOSENSORY, BRAIN-STEM AUDITORY AND PERIPHERAL SENSORY-MOTOR CONDUCTION DURING VITAMIN-E-DEFICIENCY IN THE RAT
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DOI：
10.1016/0022-510x(90)90016-g
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发表时间：
1990-12-01
影响因子：
4.4
通讯作者：
MULLER, DPR
中科院分区：
文献类型：
--
作者：
GOSSSAMPSON, MA;KRISS, A;MULLER, DPR
A severe deficiency of vitamin E causes a characteristic neurological syndrome in man and experimental animals. In this study a number of electrophysiological modalities in vitamin E deficient and control rats have been investigated over a period of one year to define the time of onset and severity of the abnormalities associated with vitamin E deficiency in the rat. The mean velocities (n = 10) of the sensory evoked potentials were slower at all time points in the vitamin E deficient rats, with the central conduction velocities being more severely affected than the peripheral. Central conduction velocities, following both tibial and median nerve stimulation, were significantly delayed (P < 0.005) after 8 months of deficiency. Differences in peripheral conduction following tibial stimulation became significantly delayed (P < 0.005) after 11 months of deficiency. There were no significant differences in the brainstem auditory evoked potentials or peripheral sensory motor responses between the vitamin E deficient and control rats over the 1 year period. These results in the rat are essentially similar to those previously reported in vitamin E deficient man.
