Macrophages in human breast disease: a quantitative immunohistochemical study.
Macrophages in human breast disease: a quantitative immunohistochemical study.
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DOI：
10.1038/bjc.1988.36
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发表时间：
1988-02
影响因子：
8.8
通讯作者：
McGee, J O
中科院分区：
文献类型：
--
作者：
Kelly, P M;Davison, R S;Bliss, E;McGee, J O
我们描述了34例乳腺活检的定量组织学研究，使用人类巨噬细胞标记物，单克隆抗体EBM/11。17例活检为恶性肿瘤。良性和恶性乳腺组织均含有大量巨噬细胞，恶性组巨噬细胞数量明显高于恶性组。根据恶性肿瘤分期、分级及预后指标对巨噬细胞计数进行分析。在恶性乳腺肿瘤中，巨噬细胞数量与上述参数均无相关性。我们讨论了一些早期研究（使用其他标记物，如溶菌酶）显示肿瘤内巨噬细胞数量明显不显著的可能原因。
We describe a quantitative histological study of 34 breast biopsies using a marker for human macrophages, the monoclonal antibody EBM/11. Seventeen of the biopsies were of malignant tumours. Both benign and malignant breast tissue contained large numbers of macrophages with significantly higher numbers occurring in the malignant group. An analysis was made of macrophage counts according to stage, grade and prognostic index of the malignant tumours. There was no correlation between macrophage numbers and any of these parameters in malignant breast tumours. We discuss the possible reasons why some earlier studies (using other markers such as lysozyme), have shown an apparently insignificant number of intratumoral macrophages.