PATERNAL ORIGIN OF THE DENOVO DELETED CHROMOSOME-4 IN WOLF-HIRSCHHORN SYNDROME
PATERNAL ORIGIN OF THE DENOVO DELETED CHROMOSOME-4 IN WOLF-HIRSCHHORN SYNDROME
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DOI：
10.1136/jmg.29.1.53
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发表时间：
1992-01-01
影响因子：
4
通讯作者：
MARASCHIO, P
中科院分区：
文献类型：
--
作者：
TUPLER, R;BORTOTTO, L;MARASCHIO, P
应用4p16.3区域的多态性探针对5例Wolf-Hirschhorn综合征4号染色体从头缺失的双亲起源进行了研究。在所有患者中，发现缺失的染色体均为父系来源，这些结果与另一组获得的类似结果一起，使得4号染色体从头缺失的优先父系来源非常显著。
The parental origin of the de novo deleted chromosome 4 was studied in five cases of Wolf-Hirschhorn syndrome using polymorphic probes mapping in the 4p16.3 region. In all the patients the deleted chromosome was found to be of paternal origin and these results, together with similar ones obtained by another group, make the preferential paternal origin of the de novo chromosome 4 deletion highly significant.