Recent advances in brain cholesterol dynamics: transport, domains, and Alzheimer's disease.
Recent advances in brain cholesterol dynamics: transport, domains, and Alzheimer's disease.
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脑胆固醇动力学的最新进展：运输、域和阿尔茨海默病。
DOI：
10.1007/s11745-999-0357-9
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发表时间：
1999
期刊：
影响因子：
1.9
通讯作者：
Igbavboa,U
中科院分区：
文献类型：
--
作者：
Wood,WG;Schroeder,F;Avdulov,NA;Chochina,SV;Igbavboa,U
在了解胆固醇动力学和胆固醇在血管疾病中的作用方面取得了重大进展。大脑是一个富含胆固醇的器官，但了解大脑胆固醇动态的进展相对有限。本文综述了最近对脑胆固醇动力学的理解，重点是细胞外和细胞内脂质载体蛋白，膜胆固醇结构域，以及胆固醇动力学与阿尔茨海默病之间联系的新证据。
Major advances in understanding cholesterol dynamics and the role that cholesterol plays in vascular disease have recently been made. The brain is an organ that is highly enriched in cholesterol, but progress toward understanding brain cholesterol dynamics has been relatively limited. This review examines recent contributions to the understanding of brain cholesterol dynamics, focusing on extracellular and intracellular lipid carrier proteins, membrane cholesterol domains, and emerging evidence linking an association between cholesterol dynamics and Alzheimer's disease.