ACUPUNCTURE AND DIFFUSE NOXIOUS INHIBITORY CONTROLS - NALOXONE-REVERSIBLE DEPRESSION OF ACTIVITIES OF TRIGEMINAL CONVERGENT NEURONS
ACUPUNCTURE AND DIFFUSE NOXIOUS INHIBITORY CONTROLS - NALOXONE-REVERSIBLE DEPRESSION OF ACTIVITIES OF TRIGEMINAL CONVERGENT NEURONS
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DOI：
10.1016/0306-4522(90)90110-p
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发表时间：
1990-01-01
期刊：
影响因子：
3.3
通讯作者：
LEBARS, D
中科院分区：
文献类型：
--
作者：
BING, Z;VILLANUEVA, L;LEBARS, D
记录是由大鼠三叉神经尾核中的会聚神经元进行的。这些神经元可以通过施加到口吻同侧部分的兴奋性感受野的无害和有害的机械刺激来激活。对兴奋场中心经皮施加阈上 2 ms 方波电刺激会导致对观察到的 A 纤维和 C 纤维的反应。将传统中国针灸师在右后肢“足三里”穴位进行的手动针灸对这些反应的影响与针刺在“足三里”旁边的非穴位所引起的影响进行比较。此外，还将针灸的效果与左后肢有害热刺激对相同神经元反应引起的抑制效果进行了比较。我们小组之前已经描述了最后一种抑制类型，并将其称为弥散性有害抑制对照。针刺，无论是在“足三里”还是在非穴位和有害的热刺激，都对三叉神经会聚神经元的 C 纤维诱发反应产生类似的强烈抑制作用（分别为 77.9 .+-. 4.4%；72.5 .+-. 4.6% 和 78.5 .+-. 3.6% 抑制），并且这些抑制之后是持久的。影响。此外，全身纳洛酮（0.4 mg/kg，静脉注射）显着降低了针灸和有害热刺激引起的抑制。由于针灸引起的镇痛作用（i）与有害热刺激引起的镇痛作用具有相似的强度和时间进程，（ii）表现出缺乏地形特异性，并且（iii）涉及阿片能联系，因此我们建议，至少在我们的实验条件下，针灸操作触发涉及弥漫性有害抑制控制的神经元机制。
Recordings were made from convergent neurons in trigeminal nucleus caudalis of the rat. These neurons could be activated by both innocuous and noxious mechanical stimuli applied to their excitatory receptive fields on the ipsilateral part of the muzzle. Percutaneous application of suprathreshold, 2 ms square-wave electrical stimuli to the centre of the excitatory field resulted in response to A- and C-fibres being observed. The effects on these response of manual acupuncture performed by a traditional Chinese acupuncturist at the "Zusanli" point on the right hindlimb were compared with the effects induced by acupuncture applied at a non-acupoint, next to "Zusanli". In addition, the effects of acupuncture were compared with the inhibitory effects evoked by noxious thermal stimulation of the left hindlimb on the responses of the same neurons. This last type of inhibition has been described previously by our group and termed diffuse noxious inhibitory controls. Acupuncture, either applied at "Zusanli" or at a non-acupoint and noxious thermal stimulation induced similar strong inhibitory effects on the C-fibre-evoked responses of trigeminal convergent neurons (77.9 .+-. 4.4%; 72.5 .+-. 4.6% and 78.5 .+-. 3.6% inhibition, respectively) and these inhibitions were followed by long-lasting afereffects. In addition, both the acupuncture- and noxious thermal stimulation-evoked inhibitions were significantly reduced by systemic naloxone (0.4 mg/kg, i.v.). Since the antinociceptive effects elicited by acupuncture (i) had a similar magnitude and time-course to those evoked by noxious thermal stimulation, (ii) exhibited a lack of topographical specificity and (iii) involved an opioidergic link, we would suggest that, at least in our experimental conditions, acupuncture manoeuvres trigger the neuronal mechanisms involved in diffuse noxious inhibitory controls.