Reproducibility and influence of test modality order on thermal perception and thermal pain thresholds in quantitative sensory testing
Reproducibility and influence of test modality order on thermal perception and thermal pain thresholds in quantitative sensory testing
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DOI：
10.1016/j.clinph.2010.03.055
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发表时间：
2010-11-01
影响因子：
4.7
通讯作者：
Nordh, Erik
中科院分区：
文献类型：
--
作者：
Heldestad, Victoria;Linder, Jan;Nordh, Erik
目的：通过评估热冷（CT）和热（WT）感知阈值以及热冷（CPT）和热痛（HPT）阈值的个体间和个体内变化，评价定量感觉测试（QST）在不同测试间隔采用限值方法（MLI）进行的重现性。在38名健康受试者中进行了三次重复和伪随机测试，在三种情况下进行了MLI的QST（第1、2和7天）。在重复测试中，当确定为第一次测试（FT）时，没有热阈值估计值显示出系统性显著差异，无论是日间还是同一天内的会话间，对于CT和WT，也在热疼痛评估（aTPA）之后。然而，当直接测定aTPA时，注意到CT和WT均显著更高。此外，变异系数和重复性表明增加值aTPA.Conclusions：高再现性表明，MLI是一种可行的热QST方法，在较短和较长的测试间隔下都具有可再现的结果，条件是在给予任何疼痛的热刺激之前确定温度阈值，因为后者影响CT和WT评估。结果表明，QST与MLI是一个可靠的工具，间接评估人类小神经纤维的功能。(C)2010年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To evaluate the reproducibility of quantitative sensory testing (QST), performed with the method-of-limits (MLI) at different test intervals, by assessing the inter-and intra-individual variation of thermal cold (CT) and warm (WT) perception thresholds, and of thermal cold- (CPT) and heat pain (HPT) thresholds.Methods: QST with the MLI was performed in 38 healthy subjects in three repeated and pseudo-randomized test sessions, done at three occasions (days 1, 2 and 7).Results: At repeated testing, none of the thermal threshold estimates showed systematic significant differences, neither between days nor between sessions within the same day, when determined as first tests (FT), and for CT and WT also after thermal pain assessment (aTPA). However, when determined directly aTPA, both CT and WT were noted significantly higher. Also the coefficients of variation and repeatability showed increased values aTPA.Conclusions: The high reproducibility show that the MLI is a feasible method for thermal QST, with reproducible results both at shorter and longer test intervals, on condition that temperature thresholds are determined before any painful thermal stimuli are given, as the latter influence both CT and WT assessments.Significance: The findings show that QST with the MLI is a reliable tool for indirect evaluation of human small nerve fiber function. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.