Prospective evaluation of luteal phase length and natural fertility
Prospective evaluation of luteal phase length and natural fertility
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DOI：
10.1016/.fertnstert.2016.11.022
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发表时间：
2017-03-01
影响因子：
6.7
通讯作者：
Steiner, Anne Z.
中科院分区：
文献类型：
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作者：
Crawford, Natalie M.;Pritchard, David A.;Steiner, Anne Z.
目标：评估短黄体期对生育力的影响。设计：前瞻性妊娠时间队列研究。设置：不适用。患者：年龄30-44岁，无已知不孕症的试图怀孕的妇女。干预措施：每日日记，排卵预测试验，标准化妊娠试验。主要结局指标：随后周期的生育力。结果：分析中包括来自284名妇女的1，635个周期。在180/0的观察周期中出现短黄体期（包括排卵日< 11天）。平均黄体期为14天。黄体期短的女性吸烟者明显更多。在调整年龄后，与没有短黄体期的女性相比，短黄体期的女性在短黄体期后立即怀孕的几率为0.82倍。在第一个观察周期的黄体长度短的妇女有显着降低生育率后的第一个6个月的怀孕尝试，但在12个月内没有显着差异的累积概率pregnancy. Conclusions（S）：虽然一个孤立的周期与黄体期短可能会对短期生育能力产生负面影响，不孕症的发病率在12个月内并没有显着高于这些妇女。
Objective: To evaluate the impact of a short luteal phase on fecundity.Design: Prospective time-to-pregnancy cohort study.Setting: Not applicable.Patient(s): Women trying to conceive, ages 30-44 years, without known infertility.Intervention(s): Daily diaries, ovulation prediction testing, standardized pregnancy testing.Main Outcome Measure(s): Subsequent cycle fecundity.Result(s): Included in the analysis were 1,635 cycles from 284 women. A short luteal phase (< 11 days including the day of ovulation) occurred in 180/0 of observed cycles. Mean luteal phase length was 14 days. Significantly more women with a short luteal phase were smokers. After adjustment for age, women with a short luteal phase had 0.82 times the odds of pregnancy in the subsequent cycle immediately following the short luteal phase compared with women without a short luteal phase. Women with a short luteal length in the first observed cycle had significantly lower fertility after the first 6 months of pregnancy attempt, but at 12 months there was no significant difference in cumulative probability of pregnancy.Conclusion(s): Although an isolated cycle with a short luteal phase may negatively affect short-term fertility, incidence of infertility at 12 months was not significantly higher among these women.