Topographical distribution and morphology of NADPH-diaphorase-stained neurons in the human claustrum
Topographical distribution and morphology of NADPH-diaphorase-stained neurons in the human claustrum
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DOI：
10.3389/fnsys.2014.00096
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发表时间：
2014-01-01
影响因子：
3
通讯作者：
Ovtscharoff, Wladimir
中科院分区：
文献类型：
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作者：
Hinova-Palova, Dimka V.;Edelstein, Lawrence;Ovtscharoff, Wladimir
我们研究了人类屏状体中nadph - diaphase阳性神经元和纤维的地形分布和形态特征。这些神经元在屏状体中分布不均。考虑到染色核周的大小和形状以及树突和轴突的特征，将烟酰胺腺嘌呤二核苷酸磷酸二磷酸（Nicotinamide adenine dinucleotide phosphate-diaphorase, NADPHd）阳性神经元按直径分为大、中、小三种类型。大的神经元直径在25 ~ 35 μ m之间，通常呈椭圆形或多极细胞体。中等神经元直径在20 ~ 25 μ m之间，呈现多极、双极和不规则胞体。小神经元直径为14 ~ 20 μ min，胞体呈椭圆形或椭圆形。根据树突特征，将这些神经元分为刺状和刺状亚型。我们的研究结果揭示了人类屏状体中存在两种nadphd阳性神经元——一种由与投射神经元表型一致的大细胞和中等细胞组成，另一种由类似于先前高尔基浸渍研究定义的中间神经元表型的小细胞组成。
We studied the topographical distribution and morphological characteristics of NADPH-diaphorase-positive neurons and fibers in the human claustrum. These neurons were seen to be heterogeneously distributed throughout the claustrum. Taking into account the size and shape of stained perikarya as well as dendritic and axonal characteristics, Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPHd)-positive neurons were categorized by diameter into three types: large, medium and small. Large neurons ranged from 25 to 35 mu m in diameter and typically displayed elliptical or multipolar cell bodies. Medium neurons ranged from 20 to 25 mu m in diameter and displayed multipolar, bipolar and irregular cell bodies. Small neurons ranged from 14 to 20 mu min diameter and most often displayed oval or elliptical cell bodies. Based on dendritic characteristics, these neurons were divided into spiny and aspiny subtypes. Our findings reveal two populations of NADPHd-positive neurons in the human claustrum-one comprised of large and medium cells consistent with a projection neuron phenotype, the other represented by small cells resembling the interneuron phenotype as defined by previous Golgi impregnation studies.