Outbreaks of acute gastroenteritis on cruise ships and on land: Identification of a predominant circulating strain of Norovirus - United States, 2002
Outbreaks of acute gastroenteritis on cruise ships and on land: Identification of a predominant circulating strain of Norovirus - United States, 2002
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DOI：
10.1086/420888
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发表时间：
2004-07-01
影响因子：
6.4
通讯作者：
Monroe, SS
中科院分区：
文献类型：
--
作者：
Widdowson, MA;Cramer, EH;Monroe, SS
2002年，诺沃克病毒相关疾病在游轮和陆地上的暴发急剧增加，鼓励我们检查检测到的诺如病毒的分子流行病学，以确定共同的毒株或来源。在邮轮上经实验室确认的14起疫情中，有12起(86%)是杯状病毒所致；在这12起疫情中，有6起(50%)疫情持续，7起(58%)出现多种传播方式，7起(>；10%)发病率较高(58%)。在12起杯状病毒暴发中，有11起是由诺如病毒引起的，其中7起(%)被归因于一个以前未被报道的谱系，暂时命名为“法明顿山病毒株”。从2002年5月至2002年12月，在22起陆上疫情中，有10起(45%)也是由这种毒株引起的。核苷酸序列分析通过记录疫情之间的联系、将毒株引入船上以及病毒在船上的持久性(尽管是清洁的)，提供了对诺沃克病毒传播的洞察。暴发的控制措施应针对所有传播途径。更好的暴发监测和序列数据收集将有助于监测诺沃克病毒株和确定共同来源。
In 2002, a sharp increase in outbreaks of norovirus-associated illness, both on cruise ships and on land, encouraged us to examine the molecular epidemiology of detected noroviruses, to identify a common strain or source. Of 14 laboratory-confirmed outbreaks on cruise ships, 12 (86%) were attributed to caliciviruses; among these 12, outbreak characteristics included continuation on successive cruises in 6 (50%), multiple modes of transmission in 7 (58%), and high (>10%) attack rates in 7 (58%). Eleven of the 12 calicivirus outbreaks were attributed to noroviruses, 7 (64%) of which were attributed to a previously unreported lineage, provisionally named "the Farmington Hills strain." From May 2002 to December 2002, 10 (45%) of 22 land-based outbreaks also were attributed to this strain. Nucleotide-sequence analysis provided insights into norovirus transmission, by documenting links among outbreaks, the introduction of strains onto ships, and viral persistence on board (despite cleaning). Control measures for outbreaks should address all routes of transmission. Better outbreak surveillance and collection of data on sequences will help to monitor norovirus strains and to identify common sources.