Non-contact photoacoustic tomography and ultrasonography for tissue imaging.
Non-contact photoacoustic tomography and ultrasonography for tissue imaging.
复制标题
用于组织成像的非接触光声断层扫描和超声检查。
DOI：
10.1364/boe.3.000016
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发表时间：
2012-01-01
影响因子：
3.4
通讯作者：
Monchalin JP
中科院分区：
文献类型：
--
作者：
Rousseau G;Blouin A;Monchalin JP
在光声断层扫描（PAT）和超声检查（US）中的超声检测通常依赖于与生物组织接触的超声换能器。这对于重要的潜在应用如外科手术和小动物成像是一个主要的缺点。在这里，我们报告使用远程光学检测，用于工业激光超声，检测生物组织中的超声。该策略可实现PAT和US的非接触式实施，而不会超过激光暴露安全限值。该方法使用适当形状的激光脉冲和共焦法布里-珀罗干涉仪的差分配置，以达到量子限制的灵敏度。内源性和外源性夹杂物表现出光学和声学对比检测离体鸡胸肉和小牛脑标本。在深度远远超过1厘米的地方检测到尺寸小至0.5毫米的夹杂物。该方法可以大大扩展PAT和US在生物医学成像中的应用范围。
The detection of ultrasound in photoacoustic tomography (PAT) and ultrasonography (US) usually relies on ultrasonic transducers in contact with the biological tissue. This is a major drawback for important potential applications such as surgery and small animal imaging. Here we report the use of remote optical detection, as used in industrial laser-ultrasonics, to detect ultrasound in biological tissues. This strategy enables non-contact implementation of PAT and US without exceeding laser exposure safety limits. The method uses suitably shaped laser pulses and a confocal Fabry-Perot interferometer in differential configuration to reach quantum-limited sensitivity. Endogenous and exogenous inclusions exhibiting optical and acoustic contrasts were detected ex vivo in chicken breast and calf brain specimens. Inclusions down to 0.5 mm in size were detected at depths well exceeding 1 cm. The method could significantly expand the scope of applications of PAT and US in biomedical imaging.