Long-term effects of lung cancer computed tomography screening on health-related quality of life: the NELSON trial
Long-term effects of lung cancer computed tomography screening on health-related quality of life: the NELSON trial
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DOI：
10.1183/09031936.00123410
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发表时间：
2011-07-01
影响因子：
24.3
通讯作者：
de Koning, H. J.
中科院分区：
文献类型：
--
作者：
van den Bergh, K. A. M.;Essink-Bot, M. L.;de Koning, H. J.
肺癌计算机断层扫描 (CT) 筛查对健康相关生活质量 (HRQoL) 的长期影响尚未得到调查。 在荷兰-比利时随机肺癌筛查试验 (NELSON 试验) 中，1,466 名参与者在随机分组前 (T0)、基线筛查后 2 个月（仅筛查组；T1）和 2 年随访时 (T2) 接受了调查问卷。 HRQoL 的测量方式为通用 HRQoL（12 项简短问卷和 EuroQoL 问卷）、焦虑（斯皮尔伯格状态特质焦虑量表）和肺癌特异性困扰（事件影响量表 (IES)）。使用方差分析的重复测量来分析筛查组和对照组之间以及不确定（需要随访 CT）和阴性筛查结果组之间的差异。在 T0 和 T2 时，筛查组和对照组之间或不确定或阴性第二轮筛查结果组之间的 HRQoL 评分随时间变化没有显着差异。基线结果不确定后，IES 分数暂时增加（T0：平均 4.0 (95% CI 2.8-5.3)；T1：平均 7.8 (95% CI 6.5-9.0)；T2：平均 4.5 (95% CI 3.3-5.8)）。在 2 年随访时，筛查受试者的 HRQoL 与对照受试者相似，不确定基线筛查结果的不利短期影响已经解决，第二轮筛查结果不确定对 HRQoL 没有影响。
The long-term effects of lung cancer computed tomography (CT) screening on health-related quality of life (HRQoL) have not yet been investigated.In the Dutch-Belgian Randomised Lung Cancer Screening Trial (NELSON trial), 1,466 participants received questionnaires before randomisation (T0), 2 months after baseline screening (screen group only; T1) and at 2-yr follow-up (T2). HRQoL was measured as generic HRQoL (12-item short-form questionnaire and EuroQoL questionnaire), anxiety (Spielberger State-Trait Anxiety Inventory) and lung cancer-specific distress (impact of event scale (IES)). Repeated measures of ANOVA were used to analyse differences between the screen and control groups, and between indeterminate (requiring a follow-up CT) and negative screening result groups.At T0 and T2 there were no significant differences in HRQoL scores over time between the screen and control groups, or between the indeterminate or negative second-round screening result group. There was a temporary increase in IES scores after an indeterminate baseline result (T0: mean 4.0 (95% CI 2.8-5.3); T1: mean 7.8 (95% CI 6.5-9.0); T2: mean 4.5 (95% CI 3.3-5.8)).At 2-yr follow-up, the HRQoL of screened subjects was similar to that of control subjects, the unfavourable short-term effects of an indeterminate baseline screening result had resolved and an indeterminate result at the second screening round had no impact on HRQoL.