Polymorphisms in the serotonin transporter and monoamine oxidase a genes and their relationship to personality traits measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in healthy volunteers
Polymorphisms in the serotonin transporter and monoamine oxidase a genes and their relationship to personality traits measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in healthy volunteers
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DOI：
10.1159/000079111
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发表时间：
2004-01-01
影响因子：
3.2
通讯作者：
Kucharska-Mazur, J
中科院分区：
文献类型：
--
作者：
Samochowiec, J;Syrek, S;Kucharska-Mazur, J
采用气质与性格量表（TCI）和NEO五因素量表（NEO-FFI）对5-HTT-LPR、单胺氧化酶A（MAOA）-LPR与气质维度的关系进行了研究。招募了100名健康志愿者（无精神疾病），代表斯切钦（波兰）人群的性别、年龄和教育水平。5-HTT-LPR与TCI伤害回避维度和NEO-FFI神经质维度之间没有相关性，携带3-VNTR MAOA基因变体（209 bp）的男性在NEO-FFI开放性维度上的值显著较低（p = 0.039），并且在TCI奖励依赖（RD 3）的子维度3（即依恋与分离）上获得更高的分数（p = 0.005）。携带5-HTT-LPR“短”变体的个体在奖励依赖维度和RD 4子维度（依赖与独立）上的值低于不携带“短”变体的个体（分别为p = 0.039和p = 0.011）。携带“短”变体的女性在NS 1（探索性兴奋性与坚忍刚性）和RD 4（依赖性与独立性）上的值低于未携带变体的女性（分别为p = 0.042和0.043）。所获得的显着性水平的5-HTT-LPR和奖励依赖量表和分量表之间的观察到的关联和5-HTT-LPR和NS 1分量表之间的太弱，无法进一步解释。我们的研究结果并没有证实这一假设，即单基因多态性和TCI和NEO-FFI量表测量的人格特质之间存在简单的相关性。版权所有（C）2004 S. Karger AG，巴塞尔。
The associations between 5-HTT-linked polymorphic region (5-HTT-LPR), monoamine oxidase A (MAOA)-LPR and the dimensions of temperament evaluated using the Temperament and Character Inventory (TCI) and NEO Five-Factor Inventory (NEO-FFI) were studied. One hundred healthy volunteers ( without psychiatric disorders) were recruited to represent a cross-section of the population of Szczecin ( Poland) in terms of sex, age and education. No associations between 5-HTT-LPR and the TCI harm avoidance dimension and between 5-HTT-LPR and the NEO-FFI neuroticism dimension were found. Males carrying the 3-VNTR MAOA gene variant (209 bp) had significantly lower values on the NEO-FFI openness dimension (p = 0.039) and obtained higher scores on the subdimension 3 of the TCI reward dependence (RD3), i.e. attachment vs. detachment (p = 0.005). Individuals carrying the 'short' variant of 5-HTT-LPR had lower values on the reward dependence dimension and the RD4 subdimension ( dependence vs. independence) than individuals not carrying the 'short' variant ( p = 0.039 and p = 0.011, respectively). Females carrying the 'short' variant had lower values on NS1 ( exploratory excitability vs. stoic rigidity) and RD4 ( dependence vs. independence) than those not carrying the variant (p = 0.042 and 0.043, respectively). The obtained level of significance with respect to the observed associations between 5-HTT-LPR and the reward dependence scales and subscales and between 5-HTT-LPR and the NS1 subscale are too weak for further interpretation. Our results do not confirm the hypothesis that there is a simple correlation between single gene polymorphisms and a personality trait measured by the TCI and NEO-FFI scales. Copyright (C) 2004 S. Karger AG, Basel.