Thrombin and brain recovery after intracerebral hemorrhage.
Thrombin and brain recovery after intracerebral hemorrhage.
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脑出血后凝血酶和大脑恢复。
DOI：
10.1161/strokeaha.108.533281
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发表时间：
2009-03
期刊：
影响因子：
8.3
通讯作者：
Xi G
中科院分区：
文献类型：
--
作者：
Hua Y;Keep RF;Gu Y;Xi G
脑出血(ICH)是一种常见的中风亚型，通常是致命的，会给幸存者带来严重的神经功能障碍。目前，缺乏有效的治疗方法来改善脑出血的预后。非物质文化遗产研究的一个被忽视的方面是开发可有效用于改善恢复的方法。虽然先前的研究表明凝血酶可导致脑出血后血脑屏障渗漏、脑水肿和神经元死亡，但我们最近的研究表明凝血酶可能在脑出血后的脑恢复中起作用。了解凝血酶影响神经发生、血管生成和可塑性的机制可能有助于脑出血后脑功能的恢复。
Intracerebral hemorrhage (ICH) is a common and often fatal subtype of stroke and produces severe neurological deficits in survivors. At present, there is lack of effective treatments that improve outcome in ICH. A neglected aspect of ICH research is the development of approaches that can be effectively used to improve recovery. Although previous studies have showed that thrombin induces blood-brain barrier leakage, brain edema and neuronal death after intracerebral hemorrhage (ICH), our recent studies have shown that thrombin may have a role in brain recovery after ICH. An understanding of the mechanisms by which thrombin affects neurogenesis, angiogenesis and plasticity may facilitate brain recovery after ICH.