Conservative treatment versus mastectomy in breast cancer tumors with macroscopic diameter of 20 millimeters or less the experience of the institut gustave‐roussy
Conservative treatment versus mastectomy in breast cancer tumors with macroscopic diameter of 20 millimeters or less the experience of the institut gustave‐roussy
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肉眼可见直径为 20 毫米或更小的乳腺癌肿瘤的保守治疗与乳房切除术的比较——古斯塔夫鲁西研究所的经验
作者：
D. Sarrazin;M. Lê;J. Rouëssé;G. Contesso;J. Petit;J. Lacour;Janine Viguier;C. Hill
1972年10月至1980年12月，在Institut Gustave Plastysy进行了一项临床试验，对肉眼检查时直径≤ 20 mm的乳腺癌肿瘤患者进行乳房切除术与局部切除加钴照射的比较。对所有患者进行了低位腋窝淋巴结清扫和临时组织学检查。如果发现一个或多个阳性淋巴结，则进行完全腋窝淋巴结清扫。该研究包括179名患者。两组之间的总体或无复发生存率均无显著差异，尽管保守治疗组的结果略好。保守治疗的结果是在92%的情况下，美学满意。试验包括对腋窝淋巴结阳性患者进行第二次随机化，以评估淋巴结区域照射的价值;在试验的这一部分中研究了72例患者。在调整腋窝淋巴结阳性数量后，两组之间没有发现显著差异，尽管无淋巴结照射组显示出比淋巴结照射组更好的结果和更少的并发症。癌症53：1209 - 1213，1984。
A clinical trial was conducted at the Institut Gustave Roussy between October 1972 and December 1980 to compare mastectomy with local excision plus Cobalt irradiation, in patients with breast cancer tumors of 20 mm in diameter or less at macroscopic examination. Low‐axillary dissection and extemporaneous histologic examination were carried out for all patients. If one or more positive nodes were found, complete axillary dissection was performed. The study included 179 patients. No significant difference was detected in either overall or relapse‐free survival between the two groups, although the conservatively treated group showed slightly better results. The results of conservative treatment were esthetically satisfactory in 92% of the cases. The trial included a second randomization for the patients with positive axillary nodes to assess the value of nodal area irradiation; 72 patients were studied in this part of the trial. No significant differences were found between the two groups after adjustment for the number of positive axillary nodes, although the no‐nodal irradiation group showed better results and less complications than the nodal irradiation group. Cancer 53:1209‐1213, 1984.