Silica-based mesoporous materials as drug delivery system for methotrexate release
Silica-based mesoporous materials as drug delivery system for methotrexate release
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DOI：
10.1080/10717540701606244
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发表时间：
2007-01-01
期刊：
影响因子：
6
通讯作者：
Picci, Nevio
中科院分区：
文献类型：
--
作者：
Carino, Ida Stefania;Pasqua, Luigi;Picci, Nevio
抗肿瘤药物甲氨蝶呤通过不同的浸泡程序被负载到硅基介孔材料上，并模拟口服给药先后释放。在合成混合物中含有16、12和10个碳原子的阳离子表面活性剂的存在下，利用自组装机制制备了不同孔径的多孔结构材料。在合成混合物中加入Al(OH)(3)，制备了纯二氧化硅样品。只有氧化铝-二氧化硅样品能够负载甲氨蝶呤。载药量和体外释放动力学是材料孔径的函数。
Antineoplastic methotrexate has been loaded through different soaking procedures on silica-based mesoporous materials and, successively, released mimicking an oral administration. The materials were prepared using a self-assembly mechanism in the presence of cationic surfactants with alkyl chain of 16, 12, and 10 carbon atoms in the synthesis mixture to obtain different pore diameter in the porous structure. Mesoporous materials were prepared as pure silica sample and in the presence of Al(OH)(3) in the synthesis mixture. Only alumina-silica samples were able to load methotrexate. The amounts of drug loaded and the in vitro release kinetics are a function of the pore size of the materials.