Clinical and treatment effects on 3H-clonidine and 3H-imipramine binding in elderly depressed patients.
Clinical and treatment effects on 3H-clonidine and 3H-imipramine binding in elderly depressed patients.
复制标题
DOI：
10.1016/0024-3205(87)90003-8
复制
发表时间：
1987-06
期刊：
影响因子：
6.1
通讯作者：
A. Georgotas;Jack W. Schweitzer;R. Mccue;M. Armour;Arnold J. Friedhoff
中科院分区：
文献类型：
--
作者：
A. Georgotas;Jack W. Schweitzer;R. Mccue;M. Armour;Arnold J. Friedhoff
测定了55岁及以上抑郁症患者的~3H-可乐定和~3H-丙咪嗪结合率。抑郁症患者与年龄、性别相匹配的对照组的~3H-可乐定或~3H-丙咪嗪结合率均无显著差异。治疗前~3H-可乐定或~3H-丙咪嗪结合度与抑郁程度无明显相关性。抗抑郁药物治疗7周后，KDof3H-丙咪嗪结合位点与汉密尔顿评分呈显著负相关。对抗抑郁药物治疗有反应和无反应的患者的受体数据没有显著差异。
3H-clonidine and3H-imipramine binding were measured in depressed patients, 55 years and older. There was no significant difference in either3H-clonidine or3H-imipramine binding between depressed patients and age- and sex-matched controls. There was no significant correlation between3H-clonidine or3H-imipramine binding and severity of depression before treatment. There was a significant negative correlation between the KDof3H-imipramine binding sites and Hamilton score over seven weeks of antidepressant treatment. There was no significant difference between receptor data of responders and nonresponders to antidepressant treatment.