Ovarian cancer survival and polymorphisms in hormone and DNA repair pathway genes
Ovarian cancer survival and polymorphisms in hormone and DNA repair pathway genes
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DOI：
10.1016/j.canlet.2006.11.011
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发表时间：
2007-06-18
期刊：
影响因子：
9.7
通讯作者：
Spurdle, Amanda B.
中科院分区：
文献类型：
--
作者：
Nagle, Christina M.;Chenevix-Trench, Georgia;Spurdle, Amanda B.
我们评估了激素和DNA修复途径基因的21个多态性与454名澳大利亚诊断为浸润性上皮性卵巢癌的妇女的生存率之间的关系。使用个人标识符跟踪队列的死亡率，这些标识符与州癌症登记记录和澳大利亚国家死亡指数相关联。卵巢癌诊断后的平均随访时间为4.63年（所有女性）和8.07年的审查组（那些活着或死于非卵巢癌原因）。在随访期间，有288例（63%）卵巢癌死亡。绝大多数多态性未观察到相关性，但有提示性证据表明卵巢癌死亡风险改变与CYP 17 5 'UTR Callele（HR 1.30; 95%CI = 1.02-1.68，p = 0.04）和SRD 5A 2 VS 9 L C等位基因（HR 0.79; 95%CI = 0.62-1.01，p = 0.06）相关。这些结果很有趣，因为在我们的澳大利亚扩展研究和其他已发表的研究中，初步证据表明这两种变体也与卵巢癌易感性增加有关。然而，鉴于这些关联的边际意义和大量的测试进行，独立的复制将是必要的，以验证这些新的发现。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
We evaluated the association between 21 polymorphisms in hormone and DNA repair pathway genes and survival among 454 Australian women diagnosed with invasive epithelial ovarian cancer. The cohort was followed for mortality using personal identifiers which were linked to state cancer registry records and the Australian National Death Index. The mean follow-up time after ovarian cancer diagnosis was 4.63 years (all women) and 8.07 years for-the censored group (those alive or dead from non-ovarian cancer causes). Two hundred and eighty-eight (63%) ovarian cancer deaths occurred during the follow-up period. No association was observed for the vast majority of polymorphisms, but there was suggestive evidence for altered risk of ovarian cancer death associated with the CYP17 5'UTR Callele (HR 1.30; 95% CI = 1.02-1.68, p = 0.04), and for the SRD5A2 VS9L C allele (HR 0.79; 95% CI = 0.62-1.01, p = 0.06). These results are interesting given tentative evidence that both of these variants are also associated with increased predisposition to ovarian cancer in our extended Australian study, and in other published studies. However, given the marginal significance of these associations and the large number of tests performed, independent replication will be necessary to validate these novel findings. (c) 2006 Elsevier Ireland Ltd. All rights reserved.