A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity
A new indole alkaloid, 7-hydroxyspeciociliatine, from the fruits of Malaysian Mitragyna speciosa and its opioid agonistic activity
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DOI：
10.1007/s11418-005-0001-7
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发表时间：
2006-01-01
影响因子：
3.3
通讯作者：
Takayama, Hiromitsu
中科院分区：
文献类型：
--
作者：
Kitajima, Mariko;Misawa, Kaori;Takayama, Hiromitsu
从马来西亚产的美帽菊（MitragynaspeciosaKorth.）以及11种已知的吲哚和羟吲哚生物碱（3 - 13）。通过光谱分析和化学转化确定了新化合物的结构。在豚鼠回肠实验中研究了新生物碱的阿片激动活性。发现该化合物对μ-阿片受体具有弱刺激作用。
A new indole alkaloid, 7-hydroxyspeciociliatine (1), was isolated from the fruits of Malaysian Mitragyna speciosa Korth., together with 11 known indole and oxindole alkaloids (3-13). The structure of the new compound was determined by spectroscopic analysis and chemical conversion. The opioid agonistic activity of the new alkaloid was investigated in guinea-pig ileum experiments. The compound was found to have a weak stimulatory effect of mu-opioid receptors.