An estimation of the number of cells in the human body
An estimation of the number of cells in the human body
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DOI：
10.3109/03014460.2013.807878
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发表时间：
2013-11-01
影响因子：
1.7
通讯作者：
Canaider, Silvia
中科院分区：
文献类型：
--
作者：
Bianconi, Eva;Piovesan, Allison;Canaider, Silvia
背景资料：所有生物体都是由单个的、可识别的细胞组成的，细胞的数量、大小和类型最终决定了生物体的结构和功能。虽然低等生物的细胞总数通常是已知的，但在高等生物中还没有定义。特别是，一个人的总细胞数的范围在10（12）和10（16）之间，它被广泛提及，但没有适当的参考文献。目的：研究和讨论组成标准成人生物体的细胞总数的理论问题。使用文献和/或数学方法对整个人体和单个器官的总细胞数进行系统计算。结果：目前估计的人类总细胞数计算的各种器官和细胞类型。这些部分数据对应的总数为3.72x10（13）.结论：从文化、生物、医学和比较建模的角度来看，了解人体以及单个器官的细胞总数是重要的。所呈现的细胞计数可以是共同努力完成总计算的起点。
Background: All living organisms are made of individual and identifiable cells, whose number, together with their size and type, ultimately defines the structure and functions of an organism. While the total cell number of lower organisms is often known, it has not yet been defined in higher organisms. In particular, the reported total cell number of a human being ranges between 10(12) and 10(16) and it is widely mentioned without a proper reference.Aim: To study and discuss the theoretical issue of the total number of cells that compose the standard human adult organism.Subjects and methods: A systematic calculation of the total cell number of the whole human body and of the single organs was carried out using bibliographical and/or mathematical approaches.Results: A current estimation of human total cell number calculated for a variety of organs and cell types is presented. These partial data correspond to a total number of 3.72 x 10(13).Conclusions: Knowing the total cell number of the human body as well as of individual organs is important from a cultural, biological, medical and comparative modelling point of view. The presented cell count could be a starting point for a common effort to complete the total calculation.