AXON CALIBER RELATED TO NEUROFILAMENTS AND MICROTUBULES IN SCIATIC NERVE FIBERS OF RATS AND MICE
AXON CALIBER RELATED TO NEUROFILAMENTS AND MICROTUBULES IN SCIATIC NERVE FIBERS OF RATS AND MICE
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DOI：
10.1002/ar.1091670402
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发表时间：
1970-01-01
影响因子：
--
通讯作者：
SAMORAJS.T
中科院分区：
文献类型：
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作者：
FRIEDE, RL;SAMORAJS.T
确定了成年小鼠和三个不同年龄大鼠坐骨神经的神经纤维中存在的神经丝和微管的数量。更多的微管比神经丝被发现在无髓鞘纤维中的微管/丝的比例被逆转在有髓鞘纤维，并发现独立的髓鞘的存在下，轴突口径的变化。一系列的回归分析表明，轴突口径相关性最好的神经丝和微管每纤维的数量之和。这种相关性仅略好于单独的神经丝。轴突口径与丝管状材料的相关性也优于与髓鞘厚度的相关性。大鼠和小鼠的结果相似，在分析的神经样本中年龄差异不明显。
The number of neurofilaments and microtubules present in nerve fibers was determined for sciatic nerves from adult mice and from rats of three different ages. More microtubules than neurofilaments were found in nonmyelinated fibers; the ratio of tubules/filaments was reversed in myelinated fibers and was found to change with axon caliber independent of the presence of a myelin sheath. A series of regression analyses indicated that axon caliber correlates best with the sum of the number of neurofilaments and microtubules per fiber. This correlation was only slightly better than that for neurofilaments alone. Axon caliber also correlated better with the filament‐tubular material than with the thickness of the myelin sheath. The results were similar for both rats and mice, and age differences were not apparent in the samples of nerves analyzed.