Amino Acids in the Saliva of Patients With Migraine
Amino Acids in the Saliva of Patients With Migraine
复制标题
DOI：
10.1046/j.1526-4610.1999.3909644.x
复制
发表时间：
1999-10
期刊：
影响因子：
--
通讯作者：
C. Rajda;János Tajti;R. Komoróczy;E. Seres;P. Klivényi;László Vécsei
中科院分区：
文献类型：
--
作者：
C. Rajda;János Tajti;R. Komoróczy;E. Seres;P. Klivényi;László Vécsei
关于偏头痛的发病机制有许多假设，但它们经常相互矛盾。除了血管假说外，临床数据表明兴奋性氨基酸可能在疾病的发展中起重要作用。本研究采用反相高效液相色谱法测定了23例无先兆偏头痛患者、14例有先兆偏头痛患者和20例正常人唾液中的游离氨基酸浓度。在两组偏头痛患者的唾液样本中，谷氨酸、丝氨酸、甘氨酸、精氨酸和酪氨酸的浓度明显高于对照组。提示引起中枢神经系统兴奋性亢进的氨基酸可能与偏头痛的发病机制有关。
There are a number of hypotheses concerning the pathogenesis of migraine, but they are frequently conflicting. In addition to the vascular hypothesis, clinical data are available that excitatory amino acids may play an important role in the development of the disease. In this study, free amino acid concentrations were measured by RP‐HPLC in the saliva of 23 migraineurs without aura, 14 migraineurs with aura, and 20 healthy subjects. Significantly higher concentrations of glutamic acid, serine, glycine, arginine, and tyrosine were found in the saliva samples of both groups of migraineurs relative to the control group. It is suggested that amino acids causing hyperexcitability in the central nervous system may be linked to the pathogenesis of migraine.