AND logic-like pH- and light-dual controlled drug delivery by surface modified mesoporous silica nanoparticles
AND logic-like pH- and light-dual controlled drug delivery by surface modified mesoporous silica nanoparticles
复制标题
通过表面改性介孔二氧化硅纳米粒子实现类似逻辑的 pH 和光双重控制药物输送
DOI：
10.1016/j.msec.2016.12.056
复制
发表时间：
2017
影响因子：
7.9
通讯作者：
Liu Guohua
中科院分区：
文献类型：
--
作者：
Zhao Junwei;He Zhaoshuai;Li Biao;Cheng Tanyu;Liu Guohua
近年来，药物控释系统已成为生物医学领域一个极具潜力的应用平台。本文以介孔分子筛MCM-41为载体，采用β-环糊精（β-CD）亚胺键和偶氮苯衍生物对介孔分子筛MCM-41进行表面修饰，制备了一种pH和光照双重控制的具有AND逻辑的货物释放体系。在pH = 7.0的磷酸盐缓冲盐水（PBS）溶液中，β-CD与偶氮苯衍生物的复合物在无365 nm紫外光照射的情况下有效地阻断了货物的转运。当酸性环境（pH = 5.0的PBS）和365 nm紫外光照射两个因素都满足时，货物完全释放，而当一个因素满足时，货物只有很少的运输。结果还表明，可以控制闸门的打开/关闭和小部分货物的释放。
Recently, the controlled drug delivery system has become a potential platform for biomedical application. Herein, we developed a pH and light-dual controlled cargo release system exhibiting AND logic based on MCM-41 mesoporous silica nanoparticles, which was surface modified usingβ-cyclodextrin (β-CD) with imine bond and azobenzene derivative. The complex ofβ-CD and azobenzene derivative effectively blocked the cargo delivery in pH = 7.0 phosphate buffered saline (PBS) solution without 365 nm UV light irradiation. The cargo was fully released when both factors of acidic environment (pH = 5.0 PBS) and 365 nm UV light irradiation were satisfied, meanwhile only very little cargo was delivered if one factor was satisfied. The result also demonstrates that the opening/closing of the gate and the release of the cargo in small portions can be controlled.