Correlation between language function and the left arcuate fasciculus detected by diffusion tensor imaging tractography after brain tumor surgery Clinical article
Correlation between language function and the left arcuate fasciculus detected by diffusion tensor imaging tractography after brain tumor surgery Clinical article
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DOI：
10.3171/2012.8.jns12348
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发表时间：
2012-11-01
影响因子：
4.1
通讯作者：
Hamada, Jun-ichiro
中科院分区：
文献类型：
--
作者：
Hayashi, Yutaka;Kinoshita, Masashi;Hamada, Jun-ichiro
Object.优势半球的弓状束紊乱被认为与语言处理障碍有关，包括传导性失语症。虽然弓状束可以在体内可视化与扩散张量成像（DTI）纤维束成像，其参与功能过程与语言尚未显示动态使用DTI纤维束成像。在本研究中，为了阐明弓状束在语言功能中的作用，我们按时间顺序评价了脑肿瘤手术后通过DTI纤维束成像检测到的弓状束术后变化与语言功能术后变化的关系。对7例左半球肿瘤位于部分弓状束附近的右利手患者进行了术前和术后弓状束面积和语言功能检查。利用DTI纤维束成像技术描绘弓状束，并计算其面积。采用西方失语症成套测验（WAB）测定语言功能。肿瘤切除后，7例患者中有5例患者的弓状束可视化增加，7例患者中有6例患者的WAB总分改善。术后弓状神经束可视面积与术前弓状神经束可视面积的相对比值增加，与术后语言功能的改善相关（p = 0.0039）。脑肿瘤手术后，可以通过DTI纤维束成像在体内按时间顺序评估左侧弓状束在语言功能中的作用。由于术后神经束可视化的增加与术后语言功能的改善显着相关，因此弓状神经束可能在语言功能中发挥重要作用，正如之前所认为的那样。此外，DTI纤维束成像检测到的弓状束的术后变化可以代表脑肿瘤患者术后语言依赖性功能结局的预测因素。(http网址：thejns.org/doi/abs/10.3171/2012.8.JNS12348
Object. Disturbance of the arcuate fasciculus in the dominant hemisphere is thought to be associated with language-processing disorders, including conduction aphasia. Although the arcuate fasciculus can be visualized in vivo with diffusion tensor imaging (DTI) tractography, its involvement in functional processes associated with language has not been shown dynamically using DTI tractography. In the present study, to clarify the participation of the arcuate fasciculus in language functions, postoperative changes in the arcuate fasciculus detected by DTI tractography were evaluated chronologically in relation to postoperative changes in language function after brain tumor surgery.Methods. Preoperative and postoperative arcuate fasciculus area and language function were examined in 7 right-handed patients with a brain tumor in the left hemisphere located in proximity to part of the arcuate fasciculus. The arcuate fasciculus was depicted, and its area was calculated using DTI tractography. Language functions were measured using the Western Aphasia Battery (WAB).Results. After tumor resection, visualization of the arcuate fasciculus was increased in 5 of the 7 patients, and the total WAB score improved in 6 of the 7 patients. The relative ratio of postoperative visualized area of the arcuate fasciculus to preoperative visualized area of the arcuate fasciculus was increased in association with an improvement in postoperative language function (p = 0.0039).Conclusions. The role of the left arcuate fasciculus in language functions can be evaluated chronologically in vivo by DTI tractography after brain tumor surgery. Because increased postoperative visualization of the fasciculus was significantly associated with postoperative improvement in language functions, the arcuate fasciculus may,play an important role in language function, as previously thought. In addition, postoperative changes in the arcuate fasciculus detected by DTI tractography could represent a predicting factor for postoperative language-dependent functional outcomes in patients with brain tumor. (http://thejns.org/doi/abs/10.3171/2012.8.JNS12348