Prospect of lung transplantation in Japan
Prospect of lung transplantation in Japan
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日本肺移植的前景
DOI：
10.1007/s11748-007-0156-0
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发表时间：
2008
影响因子：
1.2
通讯作者：
S. Fujimura
中科院分区：
文献类型：
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作者：
S. Fujimura
近年来，随着生命科学的发展，随着各学科领域的创新，肺切除术、肺切除术、支气管成形术、肺移植术等治疗进行性不可逆性肺部疾病的外科手术得以实现，使我们能够在手术后保留或改善肺功能。1963年，来自密西西比大学的James哈代博士进行了第一例肺移植手术，随后Joel库珀博士在1983年报告了他的临床系列手术的巨大成功。1，2从那时起，越来越多的肺移植主要在美国进行。根据2006年国际心肺移植学会（ISHLT）登记处报告，多达21 265例患者报告接受肺移植，单肺移植和双肺移植患者的5年生存率约为50%。3作者从事肺移植基础研究30余年，一直在寻找其临床应用的机会。然而，日本特殊的社会情况，主要是因为1968年心脏移植的发生，在很长一段时间内不允许我们在我国进行脑死亡供体的移植。肺移植手术终于在三月一日进行
Recent advances in the life sciences, in accordance with the innovations in various fields of science, realized the surgical procedures including lobectomy and pneumectomy with bronchoplasty, and lung transplantation for progressive irreversible pulmonary diseases, which allowed us the functional preservation or improvement of pulmonary function after surgery. The first surgery of lung transplantation was performed by Dr. James Hardy from the University of Mississippi in 1963, and Dr. Joel Cooper subsequently reported the monumental success of his clinical series of this procedure in 1983. 1, 2 Since then, an increasing number of lung transplantations have been performed mainly, in the United States. According to the Internal Society for Heart and Lung Transplantation (ISHLT) Registry report in 2006, as many as 21 265 patients were reported to undergo lung transplantation, with the 5-year survival rates around 50% in patients both with single-lung transplantation and with double-lung transplantation. 3The authors have participated in the basic research on lung transplantation for more than 30 years and had been looking for an opportunity for its clinical application. However, the special social situation in Japan, mainly because of the incidence of heart transplantation in 1968, did not allow us to perform transplantation from a brain-dead donor in our country for a long time. Lung transplantation was finally performed on March