Amelioration by the Natural Polyamine Spermine of Cartilage and Bone Destruction in Rats With Collagen-Induced Arthritis
Amelioration by the Natural Polyamine Spermine of Cartilage and Bone Destruction in Rats With Collagen-Induced Arthritis
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DOI：
10.1254/jphs.11241sc
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发表时间：
2012-05-01
影响因子：
3.5
通讯作者：
Yoneda, Yukio
中科院分区：
文献类型：
--
作者：
Iezaki, Takashi;Hinoi, Eiichi;Yoneda, Yukio
我们研究了天然多胺对胶原性关节炎大鼠关节软骨和骨破坏的药理学性质。每日补充精胺（SPM）而非亚精胺可显著抑制CIA大鼠后肢体积和关节炎评分的增加，并可增加软骨和滑膜组织中核因子- κ B配体受体激活因子mRNA的表达。组织学分析清楚地显示SPM对CIA大鼠滑膜关节软骨和骨破坏有明显的预防作用。特定的天然多胺对类风湿关节炎滑膜关节破坏的预防是有益的。
We investigated pharmacological properties of naturally occurring polyamines on cartilage and bone destruction seen in joints of rats with collagen-induced arthritis (CIA). Daily supplementation of spermine (SPM), but not spermidine, significantly inhibited increases in the hind paw volume and arthritis score in CIA rats, in addition to the increased mRNA expression of receptor activator of nuclear factor-kappa B ligand in both cartilage and synovial tissues. Histological analysis clearly revealed a drastic prevention by SPM of the cartilage and bone destruction in synovial joints of CIA rats. Particular natural polyamines would be beneficial for the prophylaxis of synovial joint destruction in rheumatoid arthritis.