Dysfunctional adaptive immunity during parasitic infections.
Dysfunctional adaptive immunity during parasitic infections.
复制标题
DOI：
10.2174/1573395509666131126230832
复制
发表时间：
2013-08-01
影响因子：
--
通讯作者：
Butler NS
中科院分区：
文献类型：
--
作者：
Zander RA;Butler NS
寄生虫驱动的适应性免疫功能失调是一个新兴的假说，用于解释寄生虫感染的慢性或持续性特征，以及大多数寄生虫反复感染却无法产生灭菌免疫这一现象。本综述讨论了来自寄生虫感染临床研究和实验模型的近期实例，这些实例证实了免疫功能失调在有效抗寄生虫免疫的产生和维持效率低下方面的作用。更好地理解寄生虫、宿主适应性免疫以及相关负调控回路之间的复杂相互作用，将为通过疫苗接种或免疫疗法增强对慢性寄生虫感染的抵抗力提供依据。
Parasite-driven dysfunctional adaptive immunity represents an emerging hypothesis to explain the chronic or persistent nature of parasitic infections, as well as the observation that repeated exposure to most parasitic organisms fails to engender sterilizing immunity. This review discusses recent examples from clinical studies and experimental models of parasitic infection that substantiate the role for immune dysfunction in the inefficient generation and maintenance of potent anti-parasitic immunity. Better understanding of the complex interplay between parasites, host adaptive immunity, and relevant negative regulatory circuits will inform efforts to enhance resistance to chronic parasitic infections through vaccination or immunotherapy.