Use of 11 C-4DST-PET for Imaging of Human Brain Tumors
Use of 11 C-4DST-PET for Imaging of Human Brain Tumors
复制标题
使用 11 C-4DST-PET 进行人脑肿瘤成像
DOI：
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发表时间：
2014
期刊：
影响因子：
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通讯作者：
J. Toyohara
中科院分区：
文献类型：
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作者：
T. Nariai;M. Inaji;M. Sakata;J. Toyohara
利用正电子发射断层扫描（PET）进行脑肿瘤成像是目前恶性脑肿瘤强化治疗不可缺少的一种方式。基于恶性肿瘤细胞中广泛的代谢，如葡萄糖代谢、氨基酸代谢、膜合成等，提出了许多示踪剂。其中，l-[甲基- 11c]蛋氨酸（11C-MET）是应用最广泛的脑肿瘤成像示踪剂。理论上，细胞增殖成像检测这些生化变化的上游事件，因此被认为是金标准。因此，3 ' -脱氧-3 ' - 18f -氟胸苷（18F-FLT）被提议作为细胞增殖成像的示踪剂。然而，其进入脑肿瘤更多地受到血液到肿瘤的运输而不是细胞增殖的影响。作为一种替代方案，基于其与DNA结合的机制，我们提出了4 ' -[甲基- 11c]硫胸嘧啶（11C-4DST）。相比之下，18F-FLT由于缺乏游离的3 ' -羟基而不能并入DNA。
Brain tumor imaging with positron emission tomography (PET) is now an indispensable modality for intensive treatment of malignant brain tumors. Many tracers have been proposed for this purpose based on the extensive metabolism in malignant tumor cells, such as glucose metabolism, amino acid metabolism, and membrane synthesis. Among them, l-[methyl-11C]methionine (11C-MET) is the most widely used tracer for brain tumor imaging. Theoretically, cell proliferation imaging detects the upstream events of these biochemical changes, and is therefore recognized as a gold standard. Thus, 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) was proposed as a tracer for cell proliferation imaging. However, its uptake into brain tumors is influenced more by blood-to-tumor transport than by cell proliferation. As an alternative, we proposed 4′-[methyl-11C]thiothymidine (11C-4DST) based on its mechanism of incorporation into DNA. In contrast, 18F-FLT is not incorporated into DNA due to lack of a free 3′-hydroxyl group.
DOI：
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发表时间：
2005-06
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
Wei Chen;T. Cloughesy;N. Kamdar;N. Satyamurthy;M. Bergsneider;L. Liau;P. Mischel;J. Czernin;M. P
通讯作者：
Wei Chen;T. Cloughesy;N. Kamdar;N. Satyamurthy;M. Bergsneider;L. Liau;P. Mischel;J. Czernin;M. P
DOI：
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发表时间：
2006-10
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
M. Muzi;A. Spence;F. O’Sullivan;D. Mankoff;J. Wells;J. Grierson;J. Link;K. Krohn
通讯作者：
M. Muzi;A. Spence;F. O’Sullivan;D. Mankoff;J. Wells;J. Grierson;J. Link;K. Krohn