Omega-3 fatty acids for the prevention of breast cancer: an update and state of the science.
Omega-3 fatty acids for the prevention of breast cancer: an update and state of the science.
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DOI：
10.1007/s12609-013-0112-1
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发表时间：
2013-09-01
影响因子：
0.9
通讯作者：
Gucalp, Ayca
中科院分区：
文献类型：
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作者：
Iyengar, Neil M;Hudis, Clifford A;Gucalp, Ayca
众所周知，膳食脂肪摄入量和构成会影响人类健康。使用欧米茄-3(ω-3)多不饱和脂肪酸(多不饱和脂肪酸)补充剂已获得越来越多的关注，因为它具有各种据称的健康益处，包括预防癌症。临床前证据令人鼓舞，最近的研究扩大了我们对ω-3多不饱和脂肪酸预防乳腺癌的机制的理解。然而，流行病学研究得出了好坏参半的结果。最近的人口研究试图描述可能影响ω-3多不饱和脂肪酸效果的因素，如总脂肪摄入量和ω-3与ω-6多不饱和脂肪酸摄入量的比率。一些临床试验，包括一些目前正在进行的试验，正在研究有利于改变内源性脂肪酸特征的新策略，以努力开发临床上可行的预防方法。确定最有可能从有针对性的预防方法中受益的明确的亚群可能在这项工作中至关重要。
The quantity and makeup of dietary fat intake are known to impact human health. Use of Omega-3 (ω-3) polyunsaturated fatty acid (PUFA) supplements has gained increasing attention for a variety of purported health benefits, including cancer prevention. Preclinical evidence has been encouraging and recent studies have expanded our understanding of the mechanisms by which ω-3 PUFAs may protect against breast cancer. However, epidemiologic studies have yielded mixed results. Recent population studies have attempted to delineate factors that may influence the effects of ω-3 PUFAs such as total fat intake and the ratio of ω-3 to ω-6 PUFA intake. Several clinical trials, including some currently ongoing, are investigating novel strategies that favorably alter endogenous fatty acid profiles in an effort to develop clinically feasible prevention methods. Identification of well-defined subpopulations that are most likely to benefit from a targeted prevention approach will likely be crucial in this effort.