Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection
Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection
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DOI：
10.1097/00075197-200205000-00006
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发表时间：
2002-05-01
影响因子：
3.1
通讯作者：
Frost, RA
中科院分区：
文献类型：
--
作者：
Lang, CH;Frost, RA
长期危重病导致的瘦体重减少仍然是该患者人群发病率和死亡率增加的重要风险因素。以前的研究已经证明了氮平衡的众所周知的损害结果，从增加肌肉蛋白质降解以及肌原纤维和骶骨质蛋白合成的速率下降。这种蛋白质失衡可能是由各种分解代谢剂（如肿瘤坏死因子-α、白细胞介素-1 β、白细胞介素-6或糖皮质激素）的存在或活性增加引起的，或者可能是通过对各种合成代谢激素（如生长激素或胰岛素样生长因子-1）的浓度降低或反应性降低介导的。这篇综述主要集中在最近的事态发展有关的重要性，在生长激素-胰岛素样生长因子-1轴的改变作为一种机制，所观察到的缺陷，肌肉蛋白质平衡。(C)2002年利平科特威廉姆斯威尔金斯。
The erosion of lean body mass resulting from protracted critical illness remains a significant risk factor for increased morbidity and mortality in this patient population. Previous studies have documented the well known impairment in nitrogen balance results from both an increase in muscle protein degradation as well as a decreased rate of both myofibrillar and sacroplasmic protein synthesis. This protein imbalance may be caused by an increased presence or activity of various catabolic agents, such as tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 or glucocorticoids, or may be mediated via a decreased concentration or responsiveness to various anabolic hormones, such as growth hormone or insulin-like growth factor-1. This review focuses on recent developments pertaining to the importance of alterations in the growth hormone-insulin-like growth factor-1 axis as a mechanism for the observed defects in muscle protein balance. (C) 2002 Lippincott Williams Wilkins.