Clinical effectiveness and potential long-term benefits of high-intensity focused ultrasound therapy for patients with adenomyosis.

Clinical effectiveness and potential long-term benefits of high-intensity focused ultrasound therapy for patients with adenomyosis.
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DOI:
10.1177/0300060520976492
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发表时间:
2020-12
期刊:
The Journal of international medical research
影响因子:
--
通讯作者:
Wang L
Wang L
中科院分区:
其他
文献类型:
--
作者:
Li W;Mao J;Liu Y;Zhu Y;Li X;Zhang Z;Bai X;Zheng W;Wang L

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子宫腺肌症是妇科常见病,难治性疾病。在治疗子宫腺肌症期间保留子宫仍然是一个问题。高强度聚焦超声(HIFU)在实体肿瘤的治疗中有着广泛的应用。本研究旨在对HIFU治疗子宫腺肌症的患者进行分析,初步探讨更适合HIFU治疗子宫腺肌症且疗效可靠的患者特点。在2年多的时间里,在我的妇科诊断为b子宫腺肌症并接受HIFU治疗的67名妇女被纳入本研究。我们调查了他们的症状(痛经和痛经)和子宫病变的体积的结果。我们还比较了患者的临床资料。随访时间平均为11.6±0.46个月。在用于评估痛经程度的数值评定量表中,HIFU治疗后3个月与治疗前相比,痛经评分显著降低(平均差值:−1.94,95%可信区间:−2.704 ~−1.176),然后保持稳定3 ~ 12个月。痛经有一定程度的减轻,平均差值为- 0.54(- 1.01-0.02)。HIFU是一种新的无创治疗bbb的方法,可能有助于缓解痛经。
Adenomyosis is a common and refractory disease in gynecology. Preserving the uterus during treatment for adenomyosis remains a problem. High-intensity focused ultrasound (HIFU) is widely used in treatment of solid tumors. This study aimed to analyze patients with adenomyosis who were treated by HIFU and to preliminarily examine the characteristics of patients who are more suitable for HIFU to treat adenomyosis with reliable efficacy. Over 2 years, 67 women who were diagnosed with adenomyosis and treated with HIFU at our gynecology department were included in this study. We investigated outcomes of their symptoms (dysmenorrhea and hypermenorrhea) and the volume of their uterine lesions. We also compared the patients’ clinical profiles. The women had a mean follow-up duration of 11.6 ± 0.46 months. In the numerical rating scale, used to assess the degree of dysmenorrhea, the score was significantly lower (mean difference: −1.94, 95% confidence interval: −2.704 to −1.176) 3 months after HIFU treatment compared with before treatment, then it remained stable for 3 to 12 months. Hypermenorrhea was reduced to a certain degree, with a mean difference of −0.54 (−1.01–0.02). HIFU is a new noninvasive treatment method for adenomyosis that may help relieve dysmenorrhea.
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