Metabolism of exogenously administered surfactant in the acutely injured lungs of adult rabbits.
Metabolism of exogenously administered surfactant in the acutely injured lungs of adult rabbits.
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成年兔急性损伤肺中外源性表面活性剂的代谢。
DOI：
10.1164/ajrccm/145.1.19
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Jobe,AH
中科院分区：
文献类型：
--
作者：
Lewis,JF;Ikegami,M;Jobe,AH
摘要 皮下注射 N-亚硝基-N-甲基氨基甲酸酯 (NNNMU) 诱发成年兔急性肺损伤。治疗后 24 小时测量时，这些兔子受伤肺中外源表面活性剂治疗剂量 (100 mg/kg) 中饱和磷脂酰胆碱 (Sat. PC) 的清除率与正常对照兔子相似。然而，周六总计。此时，受损肺的肺泡洗液和全肺中的 PC 池大小均显着低于对照肺 (p<0.05)，这意味着内源性表面活性剂代谢发生了改变
SUMMARY Acute lung Injury was Induced In adult rabbits with a subcutaneous Injection of N-nltroso-N-methylurethane (NNNMU). Clearance of saturated phosphatidylcholine (Sat. PC) from a treatment dose of exogenous surfactant (100 mg/kg) in the Injured lungs of these rabbits was similar to normal, control rabbits when measured 24 h after treatment. However, total Sat. PC pool sizes in both the alveolar wash and total lung at this time point were significantly lower for the injured lungs than for the control lungs (p< 0.05), Implying altered endogenous surfactant metabolism