Association of Circulating IGFBP1 Level with the Severity of Coronary Artery Lesions in Patients with Unstable Angina.
Association of Circulating IGFBP1 Level with the Severity of Coronary Artery Lesions in Patients with Unstable Angina.
复制标题
不稳定型心绞痛患者循环 IGFBP1 水平与冠状动脉病变严重程度的关联。
DOI：
10.1155/2017/1917291
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Wu X
中科院分区：
文献类型：
--
作者：
Zheng W;Lai Y;Jin P;Gu W;Zhou Q;Wu X
目标。据报道，局部IGFBP 1水平影响冠状动脉斑块的发展。本研究探讨了不稳定型心绞痛患者循环IGFBP 1水平与冠状动脉病变严重程度的关系。材料和方法。在2014年7月至2015年7月收治的112例临床诊断为不稳定型心绞痛的连续患者中，我们研究了循环IGFBP 1与冠状动脉疾病（CAD）严重程度的相关性。结果所有患者均接受了定期冠状动脉造影，其中67例被诊断为危重型CAD，45例被诊断为非危重型CAD。67例危重冠心病患者中，41例（61.19%）为多支病变，26例（38.81%）为单支病变。多支血管病变患者的IGFBP 1水平高于单支血管病变患者。IGFBP 1水平与GRACE评分呈正相关。在临床变量中，IGFBP 1水平与HDL-C相关。单独IGFBP 1（截止值20.86 ng/ml）预测CAD的敏感性为0.448，特异性为0.933。IGFBP 1与HDL-C联合预测冠心病的敏感性为0.821，特异性为0.800。结论.循环IGFBP 1水平与CAD的严重程度呈正相关。IGFBP 1与HDL-C联合检测可用于冠心病高危人群的筛查。
Aims. Local IGFBP1 level was reported to affect the development of coronary artery plaque. This study investigated the association of circulating IGFBP1 level with the severity of coronary artery lesions in patients with unstable angina. Materials and Methods. In 112 consecutive patients with clinically diagnosed unstable angina, admitted from July 2014 to July 2015, we studied the correlations of circulating IGFBP1 and the severity of coronary artery disease (CAD). Results. All patients underwent scheduled coronary angiography, and 67 cases were diagnosed with critical and 45 with noncritical CAD. Of the 67 critical CAD patients, 41 (61.19%) presented with multivessel and 26 (38.81%) with single-vessel lesions. IGFBP1 levels were higher in patients with multivessel than those with single-vessel lesions. Moreover, the IGFBP1 level was positively correlated with the GRACE score. Among clinical variables, the IGFBP1 level was correlated with HDL-C. IGFBP1 alone (cutoff 20.86 ng/ml) demonstrated a sensitivity of 0.448 and specificity of 0.933 in predicting CAD. Combination of IGFBP1 and HDL-C had a sensitivity of 0.821 and specificity of 0.800 in predicting CAD. Conclusions. Circulating IGFBP1 level positively correlated with the severity of CAD. IGFBP1, when combined with HDL-C, might be useful in screening for high risk CAD patients.