Arabidopsis SUMO E3 ligase AtMMS21 regulates root meristem development
Arabidopsis SUMO E3 ligase AtMMS21 regulates root meristem development
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DOI：
10.4161/psb.5.1.10158
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发表时间：
2010-01
影响因子：
2.9
通讯作者：
Shengchun Zhang;Yanli Qi;Chengwei Yang
中科院分区：
文献类型：
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作者：
Shengchun Zhang;Yanli Qi;Chengwei Yang
小泛素修饰物（SUMO）的接合/解接合是植物发育和对非生物胁迫反应的重要调控过程。然而，关于类素化在植物根发育中的作用知之甚少。细胞分裂素和生长素在决定拟南芥根细胞增殖和分化之间的平衡中起着至关重要的作用。SUMO E3连接酶AtMMS 21是人NSE 2/MMS 21的同源物，在人细胞中调节DNA损伤和DAN修复。本附录总结了我们最近在AtMMS 21介导的细胞分裂素信号调节根分生组织细胞增殖的论文。与野生型相比，mms 21 -1根对外源细胞分裂素的反应降低，细胞分裂素诱导的基因ARR 3、ARR 4、ARR 5和ARR 7的表达降低。此外，细胞分裂素信号传导的受体和正调节因子CRE 1和ARR 1的表达在mms 21 -1突变体植物中也减少。
The small ubiquitin modifier (SUMO) conjugation/deconjugation is an important regulatory progress in plant development and responses to abiotic stresses. However, much less is known about the roles of sumoylation in plant root development. Cytokinin and auxin play crucial roles in determining the balance between cell proliferation and cell differentiation in Arabidopsis roots. The SUMO E3 ligase AtMMS21 is a homologue of human NSE2/MMS21, which modulating DNA damage and DAN repair in human cells. This addendum summarizes our recent paper in the AtMMS21 mediating cytokinin signaling to regulate the root meristem cell proliferation. The mms21-1 roots had reduced responses to exogenous cytokinins, and decreased expression of the cytokinin-induced genes ARR3, ARR4, ARR5 and ARR7, compared with the wild type. Furthermore, the expression of CRE1 and ARR1, which both are the receptor and positive regulator of cytokinin signaling, was also reduced in the mms21-1 mutant plants.