FlyTF:: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster
FlyTF:: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster
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DOI：
10.1093/bioinformatics/btl143
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发表时间：
2006-06-15
期刊：
影响因子：
5.8
通讯作者：
Teichmann, Sarah A.
中科院分区：
文献类型：
--
作者：
Adryan, Boris;Teichmann, Sarah A.
我们提出了一个在果蝇黑腹果蝇中人工注释的位点特异性转录因子(TF)的目录。这些都是从带有转录相关基因本体(GO)注释以及结构DNA结合域分配的候选蛋白质列表中鉴定出来的。对于所有1052个候选蛋白质，应用一组定义的规则来分类来自文献和计算数据源的关于DNA结合和转录调节特性的信息。我们在果蝇中提出了一组753个转录因子，其中23个是对以前未描述的蛋白质的这一功能的新预测。
We present a manually annotated catalogue of site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. These were identified from a list of candidate proteins with transcription-related Gene Ontology (Go) annotation as well as structural DNA-binding domain assignments. For all 1052 candidate proteins, a defined set of rules was applied to classify information from the literature and computational data sources with respect to both DNA-binding and transcriptional regulatory properties. We propose a set of 753 TFs in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins.