Study on the electrochemical behaviour of the anticancer herbal drug emodin
Study on the electrochemical behaviour of the anticancer herbal drug emodin
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DOI：
10.1016/j.electacta.2006.03.082
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发表时间：
2006-08
影响因子：
6.6
通讯作者：
Liping Wang;Zongpei Zhang;B. Ye
中科院分区：
文献类型：
--
作者：
Liping Wang;Zongpei Zhang;B. Ye
用循环伏安法研究了抗癌中药大黄素在玻碳电极上的电化学行为。在0.05M NH_3-NH_4Cl（50%乙醇，pH7.2）缓冲溶液中，以100 mV/s的扫描速度，在Ep_1 =-0.688V和Ep_2 =-0.628V处出现一对准可逆氧化还原峰，在Ep_3 =-0.235V处出现一个不可逆阳极峰，这是大黄素的典型阳极峰。大黄素浓度在8.9×10 - 8 ~ 7.8×10 - 6 M范围内与不可逆阳极峰电流呈良好的线性关系。该方法不需预处理和分离，用于中草药中大黄素的测定，结果满意。此外，还通过电化学技术研究了电极过程动力学参数。
The electrochemical behaviour of the anticancer herbal drug emodin was investigated by cyclic voltammetry (CV) at glassy carbon electrode. In 0.05M NH3-NH4Cl (50% ethanol, pH 7.2) buffer solution, a pair of quasi-reversible redox peaks at potentials of Ep1=−0.688V and Ep2=−0.628V and one irreversible anodic peak, which was a typical anodic peak of emodin, at Ep3=−0.235V appeared at a scan rate of 100mV/s. The irreversible anodic peak currents are linearly related to the emodin concentrations in a range from 8.9×10−8M to 7.8×10−6M with a pre-concentration time of 80s under −0.620V. Using the established method without pretreatment and pre-separation, emodin in herbal drug was determined with satisfactory results. Moreover, the electrode process dynamics parameters were also investigated by electrochemical techniques.