Networks involved in olfaction and their dynamics using independent component analysis and unified structural equation modeling.
Networks involved in olfaction and their dynamics using independent component analysis and unified structural equation modeling.
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DOI：
10.1002/hbm.22312
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发表时间：
2014-05
影响因子：
4.8
通讯作者：
Yang QX
中科院分区：
文献类型：
--
作者：
Karunanayaka P;Eslinger PJ;Wang JL;Weitekamp CW;Molitoris S;Gates KM;Molenaar PC;Yang QX
人类嗅觉的研究是复杂的有意识的知觉和情感经验的气味的无数处理需求。结合功能磁共振成像和收敛多变量网络分析，我们研究了健康成年人嗅觉产生的BOLD信号的时空行为。实验fMRI范式被发现抵消嗅觉习惯化效应的局限性，并允许识别五个功能网络。分析描绘了可分离的神经元回路，空间集中在初级嗅觉皮层，纹状体，背外侧前额叶皮层，喙前额叶皮层/前扣带回，顶枕交界处。我们假设，这些功能网络subserve初级知觉，情感/动机和高阶嗅觉相关的认知过程。结果提供了直接的证据，证明嗅觉处理存在自上而下调制的平行网络，并清楚地区分了与嗅觉相关的大脑激活与气味相关的大脑激活。一个全面的嗅觉神经认知模型，可应用于更广泛的嗅觉功能，衰老和神经系统疾病的翻译研究。
The study of human olfaction is complicated by the myriad of processing demands in conscious perceptual and emotional experiences of odors. Combining functional magnetic resonance imaging with convergent multivariate network analyses, we examined the spatiotemporal behavior of olfactory-generated BOLD signal in healthy adults. The experimental fMRI paradigm was found to offset the limitations of olfactory habituation effects and permitted the identification of five functional networks. Analysis delineated separable neuronal circuits that were spatially centered in the primary olfactory cortex, striatum, dorsolateral prefrontal cortex, rostral prefrontal cortex/anterior cingulate, and parietal-occipital junction. We hypothesize that these functional networks subserve primary perceptual, affective/motivational and higher-order olfactory-related cognitive processes. Results provided direct evidence for the existence of parallel networks with top-down modulation for olfactory processing and clearly distinguished brain activations that were sniffing-related vs. odor-related. A comprehensive neurocognitive model for olfaction is presented that may be applied to broader translational studies of olfactory function, aging and neurological disease.