Static respiratory mechanics are unaltered in males and females with obesity.
Static respiratory mechanics are unaltered in males and females with obesity.
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肥胖的男性和女性的静态呼吸力学没有改变。
DOI：
10.1152/japplphysiol.00519.2023
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Babb,TonyG
中科院分区：
文献类型：
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作者：
Stickford,JonathonL;Bhammar,DhariniM;Balmain,BryceN;Babb,TonyG
我们检验了这样一个假设，即与肥胖相关的肺容积细分变化无关，肥胖不会降低男性和女性呼气流量、肺容积和静态肺弹性回缩压的相互关系。同时测量呼气流量，容量，和经尿道压力连续记录，而不同的呼气努力的流量-容量循环进行了压力校正，体积位移体体积描记器在男性和女性肥胖。使用闭塞技术收集静态顺应性曲线。检查了流量-体积、静压-体积和静压-流量关系。建立了等容压力-流量曲线，用于确定最大流量的临界压力。数据进行了比较，收集在瘦男性和女性。肥胖者的功能性残气量明显下降。肥胖组的肺流量、肺容量、静态弹性回缩压和最大呼气流量所需的最小压力之间的相互关系与消瘦组无显著性差异（均P> 0.05）。肥胖不改变成年男女肺流量-容积-压力的相互关系（均P> 0.05）。我们进一步探讨了与肥胖无关的静态力学的潜在性别差异，并观察到女性的最大呼气流量较低，这是由于与男性相比，女性的肺更小，上游流动阻力更大（所有P ≤ 0.05）。这些数据表明，肥胖的存在不会改变男性和女性呼气中期范围内的流量和压力的关系。此外，独立于肥胖，女性有较小的肺和更大的上游流阻，这有助于减少最大流量时，与男性相比。
We tested the hypothesis that independent of the obesity-related shift in lung volume subdivisions, obesity would not reduce the interrelationships of expiratory flow, lung volume, and static lung elastic recoil pressure in males and females. Simultaneous measurements of expiratory flow, volume, and transpulmonary pressure were continuously recorded while flow-volume loops of varying expiratory efforts were performed in a pressure-corrected, volume-displacement body plethysmograph in males and females with obesity. Static compliance curves were collected using the occlusion technique. Flow-volume, static pressure-volume, and static pressure-flow relationships were examined. Isovolume pressure-flow curves were constructed for the determination of the critical pressure for maximal flow. Data were compared with that collected in lean males and females. Individuals with obesity displayed a notable decrease in functional residual capacity. The interrelationships of flow, lung volume, static elastic recoil pressure, and the minimum pressure required for maximal expiratory flow in males and females with obesity were not different from that in lean males and females (allP> 0.05). Obesity does not alter the interrelationships of flow-volume-pressure of the lung in adult males and females (allP> 0.05). We further explored potential sex differences in static mechanics independent of obesity and observed that females have lower maximal expiratory flow due to a combination of smaller lungs and greater upstream flow resistance compared with males (allP≤ 0.05).NEW & NOTEWORTHYThe potential influence of obesity on the interrelationships between maximal expiratory flow, lung volume, and static lung elastic recoil pressure is unclear. These data show that the presence of obesity does not alter the relationship of flow and pressure across the mid-expiratory range in males and females. In addition, independent of obesity, females have smaller lungs and greater upstream flow resistance, which contributes to reduced maximal flow, when compared with males.