Radial expansion rates and tumor growth kinetics predict malignant transformation in contrast-enhancing low-grade diffuse astrocytoma.
Radial expansion rates and tumor growth kinetics predict malignant transformation in contrast-enhancing low-grade diffuse astrocytoma.
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DOI：
10.2217/cns.15.16
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发表时间：
2015-01-01
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影响因子：
--
通讯作者：
Ellingson, Benjamin M
中科院分区：
文献类型：
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作者：
Hathout, Leith;Pope, Whitney B;Ellingson, Benjamin M
背景技术背景：对比增强型低级别弥漫性星形细胞瘤是一种研究不足的侵袭性亚型，由于很少有恶变的影像学指征，其风险增加。在目前的研究中，我们测试了肿瘤生长动力学是否可以识别肿瘤恶性转化到更高的gradient.METHODS：30例未经治疗的弥漫性星形细胞瘤（WHO II）进行肿瘤进展。对比增强和T2高信号肿瘤区域被分割，并估计导致进展的两个时间点的肿瘤半径。径向扩张率被用来估计增殖和侵袭率使用biomethematical model.RESULTS：径向扩张率的对比增强（p = 0.0040）和T2高信号区（p = 0.0016）是显着较高的WHO II-IV肿瘤相比，nontransformers。同样，模型估计显示显着较高的增殖（p = 0.0324）和侵袭率（p = 0.0050）在WHO II-IV肿瘤相比nontransformers.CONCLUSION：肿瘤生长动力学可以识别对比度增强弥漫性星形细胞瘤恶性转化。
BACKGROUND: Contrast-enhancing low-grade diffuse astrocytomas are an understudied, aggressive subtype at increased risk because of few radiographic indications of malignant transformation. In the current study, we tested whether tumor growth kinetics could identify tumors that undergo malignant transformation to higher grades.METHODS: Thirty patients with untreated diffuse astrocytomas (WHO II) that underwent tumor progression were enrolled. Contrast-enhancing and T2 hyperintense tumor regions were segmented and the radius of tumor at two time points leading to progression was estimated. Radial expansion rates were used to estimate proliferation and invasion rates using a biomathematical model.RESULTS: Radial expansion rates for both contrast-enhancing (p = 0.0040) and T2 hyperintense regions (p = 0.0016) were significantly higher in WHO II-IV tumors compared with nontransformers. Similarly, model estimates showed a significantly higher proliferation (p = 0.0324) and invasion rate (p = 0.0050) in WHO II-IV tumors compared with nontransformers.CONCLUSION: Tumor growth kinetics can identify contrast-enhancing diffuse astrocytomas undergoing malignant transformation.